{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:17:01Z","timestamp":1777727821242,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Functional MRI (fMRI) is gaining importance in the preoperative assessment of language for presurgical planning. However, inconsistencies with the Wada test might arise. This current case report describes a very rare case of an epileptic patient who exhibited bilateral distribution (right\u2009&gt;\u2009left) in the inferior frontal gyrus (laterality index [LI]\u2009=\u2009\u20130.433) and completely right dominance in the superior temporal gyrus (LI\u2009=\u2009\u20131). However, the Wada test revealed a dissociation: his motor speech was located in the left hemisphere, while he could understand vocal instructions with his right hemisphere. A clinical implication is that the LIs obtained by fMRI should be cautiously used to determine Broca\u2019s area in atypical patients; for example, even when complete right dominance is found in the temporal cortex in right-handed patients. Theoretically, as the spatially separated functions of motor speech and language comprehension (by the combined results of fMRI and Wada) can be further temporally separated (by the intracarotid amobarbital procedure) in this case report, these findings might provide direct support to Broca\u2019s initial conclusions that Broca\u2019s area is associated with acquired motor speech impairment, but not language comprehension per se. Moreover, this current finding supports the idea that once produced, motor speech can be independent from language comprehension.<\/jats:p>","DOI":"10.1177\/03000605241265338","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T06:03:59Z","timestamp":1726639439000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Discordant Wada and fMRI language lateralization: a case report"],"prefix":"10.1177","volume":"52","author":[{"given":"Yu","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics (MOE and Shanghai), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics (MOE and Shanghai), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China"},{"name":"Shanghai Changning Mental Health Centre, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"bibr1-03000605241265338","first-page":"1","author":"Ailion A","year":"2023","journal-title":"Clin 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