{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:46:31Z","timestamp":1790804791559,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides\/high-density lipoprotein cholesterol (TG\/HDL-c) ratio, adiponectin\/leptin (A\/L) ratio) were compared between cases and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, POM cases had significantly higher values of HOMA-IR and TG\/HDL-c ratio, and significantly lower values of A\/L and vitamin D. HOMA-IR and TG\/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A\/L ratio were statistically significantly negatively correlated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241270648","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:24:58Z","timestamp":1724124298000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Periorbital melanosis and its possible association with insulin resistance and vitamin D deficiency: A pilot case-control study"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-8701","authenticated-orcid":false,"given":"Sara I.","family":"Taha","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamyaa","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Mohamad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahy","family":"El-Bassiouny","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Adham","family":"El-Mohamdy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"bibr1-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/479354"},{"key":"bibr2-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.127675"},{"key":"bibr3-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.101371"},{"key":"bibr4-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_491_20"},{"key":"bibr5-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01213.x"},{"key":"bibr6-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18576"},{"key":"bibr7-03000605241270648","unstructured":"Pedersen O. [Insulin resistance\u2013a physiopathological condition with numerous sequelae: non-insulin-dependent diabetes mellitus (NIDDM), android obesity, essential hypertension, dyslipidemia and atherosclerosis].\n                      Ugeskr Laeger\n                      1992; 154: 1411\u20131418. [Article in Danish]."},{"key":"bibr8-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.94275"},{"key":"bibr9-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.104122"},{"key":"bibr10-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.01.005"},{"key":"bibr11-03000605241270648","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020454"},{"key":"bibr12-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.120720"},{"key":"bibr13-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2656321"},{"key":"bibr14-03000605241270648","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061743"},{"key":"bibr15-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.016"},{"key":"bibr16-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3788.501"},{"key":"bibr17-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.09.017"},{"key":"bibr18-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0558-y"},{"key":"bibr19-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1159\/000354750"},{"key":"bibr20-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"bibr21-03000605241270648","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2020\/149"},{"key":"bibr22-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02065.x"},{"key":"bibr23-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13544"},{"key":"bibr24-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009608"},{"key":"bibr25-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg602"},{"key":"bibr26-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"bibr27-03000605241270648","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"bibr28-03000605241270648","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20172205"},{"key":"bibr29-03000605241270648","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_158_18"},{"key":"bibr30-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610260045007"},{"key":"bibr31-03000605241270648","unstructured":"Strachan T and Read AP. Genes in pedigrees and population. In: Strachan T, editor. Human Molecular Genetics. 3rd edition. New York: Garland Science; 2003: 106\u2013107."},{"key":"bibr32-03000605241270648","unstructured":"Matulewicz N and Karczewska-Kupczewska M. Insulin resistance and chronic inflammation.\n                      Postepy Hig Med Dosw (Online)\n                      2016; 70: 1245\u20131258."},{"key":"bibr33-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29069"},{"key":"bibr34-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135846"},{"key":"bibr35-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.04.012"},{"key":"bibr36-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01405.x"},{"key":"bibr37-03000605241270648","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.557"},{"key":"bibr38-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(00)00145-8"},{"key":"bibr39-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00309.2022"},{"key":"bibr40-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr41-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/493213"},{"key":"bibr42-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0465"},{"key":"bibr43-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/634195"},{"key":"bibr44-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.013"},{"key":"bibr45-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10343"},{"key":"bibr46-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.820"},{"key":"bibr47-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.001"},{"key":"bibr48-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9831"},{"key":"bibr49-03000605241270648","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131029498"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241270648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241270648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241270648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:19Z","timestamp":1777459819000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241270648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1177\/03000605241270648"],"URL":"https:\/\/doi.org\/10.1177\/03000605241270648","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"article-number":"03000605241270648"}}