{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:57:10Z","timestamp":1791338230983,"version":"4.3.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial investigated whether the regional cerebral oxygenation saturation (rScO\n                      <jats:sub>2<\/jats:sub>\n                      )-guided lung-protective ventilation strategy could improve brain oxygen and reduce the incidence of postoperative delirium (POD) in patients older than 65 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial enrolled 120 patients undergoing thoracic surgery who received one-lung ventilation (OLV). Patients were randomly assigned to the lung-protective ventilation group (PV group) or rScO\n                      <jats:sub>2<\/jats:sub>\n                      -oriented lung-protective ventilation group (TPV group). rScO\n                      <jats:sub>2<\/jats:sub>\n                      was recorded during the surgery, and the occurrence of POD was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of POD 3 days after surgery\u2014the primary outcome\u2014was significantly lower in the TPV group (23.3% versus 8.5%). Meanwhile, the levels of POD-related biological indicators (S100\u03b2, neuron-specific enolase, tumor necrosis factor-\u03b1) were lower in the TPV group. Considering the secondary outcomes, both groups exhibited a lower oxygenation index after OLV, whereas partial pressure of carbon dioxide and mean arterial pressure were significantly increased in the TPV group. In addition, minimum rScO\n                      <jats:sub>2<\/jats:sub>\n                      during surgery and mean rScO\n                      <jats:sub>2<\/jats:sub>\n                      were higher in the TPV group than in the PV group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous intraoperative monitoring of brain tissue oxygenation and active intervention measures guided by cerebral oxygen saturation are critical for improving brain metabolism and reducing the risk of POD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241274604","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T06:51:27Z","timestamp":1726296687000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of optimizing cerebral oxygen saturation on postoperative delirium in older patients undergoing one-lung ventilation for thoracoscopic surgery"],"prefix":"10.1177","volume":"52","author":[{"given":"Peilan","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Ganyu Hospital Affiliated to Kangda College of Nanjing Medical University, Lianyungang, China"},{"name":"Department of Anesthesiology, the Affiliated Clinical College of Yangzhou Medical College, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ganyu Hospital Affiliated to Kangda College of Nanjing Medical University, Lianyungang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ganyu Hospital Affiliated to Kangda College of Nanjing Medical University, Lianyungang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-5907","authenticated-orcid":false,"given":"Qingxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai East Clinical Medical College, Nanjing Medical University, Nanjing, China"},{"name":"Department of Anesthesiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"bibr1-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2015.06.013"},{"key":"bibr2-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.02.054"},{"key":"bibr3-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1500030"},{"key":"bibr4-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen275"},{"key":"bibr5-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1177\/21514593211058947"},{"key":"bibr6-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer501"},{"key":"bibr7-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.10.054"},{"key":"bibr8-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2493-9"},{"key":"bibr9-03000605241274604","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.889637"},{"key":"bibr10-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-9954-2"},{"key":"bibr11-03000605241274604","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06654-6"},{"key":"bibr12-03000605241274604","first-page":"340","volume":"1","author":"Kenneth 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