{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:56:38Z","timestamp":1777726598653,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Eriskin Asi Dernegi","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational, single-center study included 114 patients diagnosed with acute leukemia. Tregs percentages were measured using flow cytometry. Statistical analyses involved logistic regression to identify factors significantly associated with survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 114 patients, 78 recovered, while 36 died. The median Treg percentages were 5.9% in patients under 65 years and 5.38% in those 65 and older. A lower percentage of Tregs was associated with higher mortality in the older group (p\u2009=\u20090.04). Multivariate analysis highlighted the presence of comorbidities, documented infections, and day seven C-reactive protein levels as significant predictors of survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports the importance of monitoring chronic diseases and infection foci alongside traditional markers like C-reactive protein. Future research should explore the mechanistic roles of Tregs in immunosuppression and survival in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241276482","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:41:47Z","timestamp":1741772507000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-4819","authenticated-orcid":false,"given":"Sebnem","family":"Calik","sequence":"first","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Bilgir","sequence":"additional","affiliation":[{"name":"Hematology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail","family":"Demir","sequence":"additional","affiliation":[{"name":"\u0130nternal Diseases Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Tosun","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeliz","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"Turkish Hematology Association. National diagnosis and treatment guide 2018 adult acute myeloid leukemia (non-acute promyelocytic leukemia) diagnosis and treatment guide https:\/\/www.thd.org.tr\/thdData\/Books\/1648\/eriskin-akut-myeloid-losemi-akut-promyelositik-losemi-disi.pdf (2018 accessed 25 June 2024)."},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.12.006"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224299"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175635"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/426815"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2019.047"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0123"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/20499361221138346"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000069345.78884.0F"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1337-8"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0764-4"},{"key":"e_1_3_6_15_2","unstructured":"Rebuplic of Turkey Ministry of Health. 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