{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:08:03Z","timestamp":1777727283640,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2022D01C311"],"award-info":[{"award-number":["2022D01C311"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-\u03baB and NF-\u03baB p65. Serum levels of amylase (\u03b1-AMY), tumour necrosis factor-\u03b1 (TNF-\u03b1), interleukin (IL)-6 and IL-8 were also compared between groups of rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-\u03baB and NF-\u03baB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. \u03b1-AMY, TNF-\u03b1 and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24\u2009h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum IMA level was associated with inflammatory markers and NF-\u03baB p65 in rats with AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241287163","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:56:49Z","timestamp":1730282209000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-\n                    <b>\u03ba<\/b>\n                    B-mediated inflammatory response"],"prefix":"10.1177","volume":"52","author":[{"given":"Cheng","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tigu","family":"A","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongde","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, 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