{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:08:50Z","timestamp":1777727330125,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52\/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52\/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud\u2019s phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient\u2019s labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sj\u00f6gren\u2019s syndrome (SS) to exhibit isolated anti-Ro52\/SS-A antibody and ACA without anti-Ro60\/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52\/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52\/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon.<\/jats:p>","DOI":"10.1177\/03000605241293986","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T02:45:26Z","timestamp":1730861126000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sj\u00f6gren\u2019s syndrome positive for isolated anti-Ro52\/SS-A antibody and anti-centromere antibody"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-6348","authenticated-orcid":false,"given":"Hideki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinya","family":"Nagata","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Akiya","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotake","family":"Inomata","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ya","family":"Asatani","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-988X","authenticated-orcid":false,"given":"Noboru","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Kitano","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Iwabuchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Ishige","sequence":"additional","affiliation":[{"name":"Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Hao","sequence":"additional","affiliation":[{"name":"Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"bibr1-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev200"},{"key":"bibr2-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.07.003"},{"key":"bibr3-03000605241293986","doi-asserted-by":"publisher","DOI":"10.3109\/08916930008994077"},{"key":"bibr4-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1418164"},{"key":"bibr5-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08911-z"},{"key":"bibr6-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105895"},{"key":"bibr7-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1186\/ar1848"},{"key":"bibr8-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2021.1919342"},{"key":"bibr9-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06299-5"},{"key":"bibr10-03000605241293986","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1115548"},{"key":"bibr11-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-140"},{"key":"bibr12-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"bibr13-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr14-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1111\/jtxs.12356"},{"key":"bibr15-03000605241293986","first-page":"S177","volume":"32","author":"S\u00e1nchez-Montalv\u00e1 A","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"bibr16-03000605241293986","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6277"},{"key":"bibr17-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4063-8"},{"key":"bibr18-03000605241293986","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.110"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241293986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241293986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241293986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:09Z","timestamp":1777459749000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241293986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/03000605241293986"],"URL":"https:\/\/doi.org\/10.1177\/03000605241293986","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"article-number":"03000605241293986"}}