{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:21Z","timestamp":1777727361967,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maternal and Children Health Project of Jiangsu Province","award":["F202158"],"award-info":[{"award-number":["F202158"]}]},{"name":"Scientific Research Project of Jiangsu Maternal and Children Health Care Association","award":["FYX202118"],"award-info":[{"award-number":["FYX202118"]}]},{"name":"Changzhou Sci&Tech Program","award":["CJ20210062"],"award-info":[{"award-number":["CJ20210062"]}]},{"name":"the National Key R&D Program of China","award":["2022YFC2703400"],"award-info":[{"award-number":["2022YFC2703400"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to analyse the causes of foetal mild-to-moderate isolated ventriculomegaly (IVM) and to evaluate the prognosis of neurological development in surviving children in different subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied mild-to-moderate IVM diagnosed by prenatal ultrasound scans in different subgroups according to the laterality of IVM, the degree of IVM and foetal sex independently. The results of foetal chromosomal microarray analysis, virological tests of umbilical cord blood or amniotic fluid, foetal magnetic resonance imaging and ultrasound were collected. Long-term follow-up was performed to assess the neurodevelopment of children within 66 months through telephone interviews and\/or the Ages and Stages Questionnaire-3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The moderate group showed more chromosomal abnormalities (16.2% vs. 4.1%) and greater structural anomalies in the brain (31.8% vs. 7.5%) than the mild group. Female foetuses showed more structural anomalies than male foetuses (25.0% vs. 7.2%). However, an adverse prognosis of children was not different across the different subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate IVM may be more strongly associated with chromosomal aberrations and structural malformations than mild IVM. However, the adverse prognosis of children was similar between the different subgroups analysed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241301879","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:22:08Z","timestamp":1733718128000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Subgroup analysis of imaging scans, invasive examinations and prognosis in mild-to-moderate isolated foetal cerebral ventriculomegaly: a retrospective study in China"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-1292","authenticated-orcid":false,"given":"Chun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"},{"name":"Department of Obstetrics and Gynecology, Changzhou Second People\u2019s Hospital Affiliated to Nanjing Medical University, Changzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-0000","authenticated-orcid":false,"given":"Xia","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Children Healthcare, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"},{"name":"Nanjing Medical Key Laboratory of Female Fertility Preservation and Restoration, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengchang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis, Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital), Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"bibr1-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.04.039"},{"key":"bibr2-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.08.182"},{"key":"bibr3-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04384-w"},{"key":"bibr4-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2378"},{"key":"bibr5-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77400-8"},{"key":"bibr6-03000605241301879","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj208850"},{"key":"bibr7-03000605241301879","first-page":"1","volume":"12","author":"Start AO","year":"2021","journal-title":"Prenat Diagn"},{"key":"bibr8-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182732b53"},{"key":"bibr9-03000605241301879","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2010.541304"},{"key":"bibr10-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19038"},{"key":"bibr11-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001683"},{"key":"bibr12-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0686-8"},{"key":"bibr13-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01150-9"},{"key":"bibr14-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.6000"},{"key":"bibr15-03000605241301879","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1007507"},{"key":"bibr16-03000605241301879","first-page":"660","volume":"53","author":"He M","year":"2018","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"bibr17-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.477"},{"key":"bibr18-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2020.01.016"},{"key":"bibr19-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1863941"},{"key":"bibr20-03000605241301879","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ajog.2020.12.852","volume":"224","author":"Hu T","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"bibr21-03000605241301879","doi-asserted-by":"publisher","DOI":"10.2174\/1566524017666170303125529"},{"key":"bibr22-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519853405"},{"key":"bibr23-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.048"},{"key":"bibr24-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15943"},{"key":"bibr25-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4470"},{"key":"bibr26-03000605241301879","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.3.257"},{"key":"bibr27-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17475"},{"key":"bibr28-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31723-8"},{"key":"bibr29-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20197"},{"key":"bibr30-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20269"},{"key":"bibr31-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21974"},{"key":"bibr32-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01003.x"},{"key":"bibr33-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7307"},{"key":"bibr34-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22155"},{"key":"bibr35-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1080\/14767050601036188"},{"key":"bibr36-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01050.x"},{"key":"bibr37-03000605241301879","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20111"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241301879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241301879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241301879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:13Z","timestamp":1777459753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241301879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/03000605241301879"],"URL":"https:\/\/doi.org\/10.1177\/03000605241301879","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"article-number":"03000605241301879"}}