{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:00:27Z","timestamp":1793826027196,"version":"4.6.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate characteristics and outcomes in critically ill patients with Guillain\u2013Barr\u00e9 syndrome (GBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive adults with GBS who required intensive care unit (ICU) admission at a tertiary-care hospital between 1999 and 2020 were enrolled into this retrospective cohort study. Demographics, clinical data and patient outcomes were compared between patients who did or did not receive mechanical ventilation (MV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, the number of ICU admissions gradually rose from approximately 900 to 3000 annually. Forty-three patients had GBS and were included, of whom, 27 (62.8%) received MV for a median of 13 days. The MV group stayed longer in the ICU (median, 26 versus 6 days) and in the hospital (median, 120 versus 39 days) than the non-MV group. Most patients in the MV group (22 [81.5%]) required tracheostomy. At maximum follow-up, Hughes Functional Grading scores were 0 (full recovery) in 11 patients (25.5%), 1\u20133 in 18 (41.8%), 4\u20135 in 12 (27.9%), and 6 (death) in two (4.6%, both in the MV group), with higher median Hughes score in the MV group (3 versus 0.5). Complications during ICU and hospital stay included: veinous thromboembolism in five (11.6%), gastrointestinal bleeding in three (7.0%), bacteremia in five (11.6%), bedsore in one (2.3%), and GBS-treatment side effects in four (9.4%) patients; all of these complications occurred within the MV group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GBS was an uncommon reason for ICU admission. The findings highlight significant morbidity with GBS, particularly among patients who need MV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241306655","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T16:41:15Z","timestamp":1735058475000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and outcomes of patients with Guillain\u2013Barr\u00e9 syndrome who were admitted to the intensive care unit: a retrospective observational study"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-6756","authenticated-orcid":false,"given":"Samah","family":"Alqahtani","sequence":"first","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-8949","authenticated-orcid":false,"given":"Hasan M","family":"Al-Dorzi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatim","family":"Arishi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Peeran","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Neurology Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felwa","family":"Bin Humaid","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan Zayed","family":"Alenezi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesna","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musharaf","family":"Sadat","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Neurology Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-6241","authenticated-orcid":false,"given":"Yaseen M","family":"Arabi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"bibr1-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00517-1"},{"key":"bibr2-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1159\/000324710"},{"key":"bibr3-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0332-1"},{"key":"bibr4-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00044"},{"key":"bibr5-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.11.1662"},{"key":"bibr6-03000605241306655","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00552"},{"key":"bibr7-03000605241306655","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.117582"},{"key":"bibr8-03000605241306655","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_995_14"},{"key":"bibr9-03000605241306655","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S187994"},{"key":"bibr10-03000605241306655","first-page":"6","volume":"3","author":"Zaheer M","year":"2008","journal-title":"Pak J Neurol Sci"},{"key":"bibr11-03000605241306655","first-page":"1403","volume":"51","author":"Ali MI","year":"2006","journal-title":"Respir Care"},{"key":"bibr12-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-015-1365-7"},{"key":"bibr13-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2014.09.003"},{"key":"bibr14-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2010.01022.x"},{"key":"bibr15-03000605241306655","doi-asserted-by":"publisher","DOI":"10.4103\/1118-8561.115256"},{"key":"bibr16-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"bibr17-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.05.065"},{"key":"bibr18-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02314-5"},{"key":"bibr19-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"bibr20-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70130-8"},{"key":"bibr21-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.121"},{"key":"bibr22-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1114525"},{"key":"bibr23-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:5:3:230"},{"key":"bibr24-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-11-101"},{"key":"bibr25-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027351"},{"key":"bibr26-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00742-z"},{"key":"bibr27-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003482"},{"key":"bibr28-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15204"},{"key":"bibr29-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.014"},{"key":"bibr30-03000605241306655","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2022.18.1.48"},{"key":"bibr31-03000605241306655","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.051136"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241306655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241306655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241306655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:19Z","timestamp":1777459759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241306655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/03000605241306655"],"URL":"https:\/\/doi.org\/10.1177\/03000605241306655","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"article-number":"03000605241306655"}}