{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:18:52Z","timestamp":1777727932084,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Foundation for Primary Health Care"},{"name":"The Hospital District of Helsinki and Uusimaa"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether there is an association between maternal mental health, purchase of psychotropic drugs, socioeconomic status and major congenital anomalies in offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A register-based cohort study of 6189 Finnish primiparous women who had a singleton delivery between 2009 and 2015. Data on pregnancy and delivery outcomes, psychiatric diagnosis, prescription drug purchases and offspring congenital anomalies were obtained from Finnish national registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Severe depressive disorders were diagnosed in 2.0% of women and severe anxiety disorders in 1.1%. During pregnancy, 9.6% of women purchased psychotropic drugs. Of these women, 5.7% delivered an offspring with a major congenital anomaly. Women who purchased psychotropic drugs in pregnancy had an increased risk of delivering a child with major congenital anomalies compared with women who did not purchase psychotropic drugs. Multivariate regression analysis showed that purchase of benzodiazepines increased the risk of major congenital anomalies (odds ratio 2.11 [95% confidence interval 1.17 to 3.81]). Pregnant women purchasing psychotropic drugs more often lived alone and smoked, had higher body mass index, and had lower annual income and educational attainment than women not purchasing psychotropic drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Benzodiazepine use, but not socioeconomic status, may be associated with major congenital abnormalities in offspring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241306902","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:27:08Z","timestamp":1737005228000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal mental disorders, psychotropic drugs, socioeconomic status, and offspring congenital anomalies"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-7857","authenticated-orcid":false,"given":"Satu-Maarit","family":"Bj\u00f6rkstedt","sequence":"first","affiliation":[{"name":"Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Social Services and Health Care Division, City of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Koponen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"},{"name":"Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Gissler M","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare, Helsinki, Finland"},{"name":"Karolinska Institute and Region Stockholm, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pennanen","sequence":"additional","affiliation":[{"name":"Wellbeing services county of Vantaa and Kerava, City of Vantaa and City of Kerava, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"},{"name":"Department of Obstetrics and Gynecology and Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University Singapore, Singapore"},{"name":"Agency for Science, Technology and Research (A*STAR), Singapore Institute for Clinical Sciences (SICS), Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-1514","authenticated-orcid":false,"given":"Merja K","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"bibr1-03000605241306902","unstructured":"https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/surveillancemanual\/resource-library\/Birth-DefectsSurveillance-A-Manual-for-Programme-Managers-2020."},{"key":"bibr2-03000605241306902","first-page":"1","volume":"42","author":"Baldacci S","year":"2018","journal-title":"Epidemiol Prev"},{"key":"bibr3-03000605241306902","unstructured":"WHO Birth Defect Surveillance. 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