{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:18:52Z","timestamp":1777727932230,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Coco Industries Pty Ltd"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The cardiac return assist blanket (CRAB) has been designed to increase central venous pressure (CVP) to manage severe hypotension associated with anaphylaxis. This interventional study aimed to identify the relationship between CRAB pressure and CVP. CRAB pressure was also compared with the change in CVP associated with a straight leg raise (SLR), the Trendelenburg position, and 1\u2009L of compound sodium lactate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen healthy, fasted volunteers were exposed to CRAB pressure at 10, 20, 30, and 40\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, the SLR, and 15 degrees of the Trendelenburg position. The volunteers were then fed and hydrated with 1\u2009L of CSL over 30 minutes and the protocol was repeated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The initial 10\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O of CRAB pressure increased CVP by 3.7\u2009mmHg (95% confidence interval 2.7, 4.7). Each subsequent 10-cmH\n                      <jats:sub>2<\/jats:sub>\n                      O rise in CRAB pressure increased CVP by 0.9\u2009mmHg (95% confidence interval 0.55, 1.25). The SLR, Trendelenburg position, and 1\u2009L of CSL increased CVP by 0.97\u2009, 0.75\u2009, and 0.69\u2009mmHg, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The CRAB controllably increases CVP, and 40\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O of CRAB pressure increases CVP by 6.41\u2009mmHg. The effect of the CRAB is greater than that with the SLR, Trendelenburg position, or 1\u2009L of CSL. This trial was registered with the ANZCTR (ACTRN12621000840886: https:\/\/www.anzctr.org.au ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241307775","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:20:39Z","timestamp":1736220039000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac return assist blanket (CRAB) safely increases central venous pressure"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-7342","authenticated-orcid":false,"given":"Christopher","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"Institute for Health Research, the University of Notre Dame Australia, Department of Research, Sir Charles Gairdner Hospital, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"bibr1-03000605241307775","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.04.004"},{"key":"bibr2-03000605241307775","volume-title":"NAP 6. 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