{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:18:56Z","timestamp":1777727936465,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Nirmatrelvir\/ritonavir is a novel drug combination authorized by the US Food and Drug Administration for the treatment of coronavirus disease 2019 (COVID-19). This report describes the case of a patient with a prior history of kidney transplantation who received nirmatrelvir\/ritonavir. In this case, sirolimus use was successfully stopped before nirmatrelvir\/ritonavir treatment, and the nirmatrelvir\/ritonavir trough concentration was determined. During nirmatrelvir\/ritonavir treatment, the sirolimus trough concentration remained stable. This case highlights the risk associated with the concomitant administration of sirolimus and nirmatrelvir\/ritonavir. Providers should therefore be cautious when prescribing nirmatrelvir\/ritonavir to kidney transplant recipients currently receiving sirolimus, with caution exercised based on creatinine clearance.<\/jats:p>","DOI":"10.1177\/03000605241307845","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:23:46Z","timestamp":1735881826000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The interaction between nirmatrelvir\/ritonavir and sirolimus: a case report of a kidney recipient with renal insufficiency and COVID-19"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-8714","authenticated-orcid":false,"given":"Yinhua","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Pharmacy, the First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, the First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, the First Affiliated Hospital of Soochow University"},{"name":"Department of Pharmacy, Lianyungang Maternal and Child Health Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, the First Affiliated Hospital of Soochow University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"bibr1-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr2-03000605241307845","unstructured":"https:\/\/www.fda.gov\/drugs\/development-approval-process-drugs\/drug-trials-snapshots-paxlovid."},{"key":"bibr3-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106997"},{"key":"bibr4-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823e7884"},{"key":"bibr5-03000605241307845","unstructured":"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/sirolimus-marketed-rapamune-information."},{"key":"bibr6-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001014"},{"key":"bibr7-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2022.03.005"},{"key":"bibr8-03000605241307845","doi-asserted-by":"publisher","DOI":"10.1177\/03000605241247705"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241307845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605241307845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605241307845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:51Z","timestamp":1777459851000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605241307845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/03000605241307845"],"URL":"https:\/\/doi.org\/10.1177\/03000605241307845","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"03000605241307845"}}