{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:41:58Z","timestamp":1793230918712,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Central nervous system complications of acute pancreatitis (AP) can result in cerebral edema (CE). We assessed the risk of serious outcomes and health care features associated with CE in patients hospitalized with AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the National Inpatient Sample database. Patients were divided into the AP-CE group that developed CE and the AP-only group that did not. Outcome data were analyzed using Stata software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 543,464 patients hospitalized with AP, 220 (0.04%) developed CE. In multivariate analysis, primary outcomes included increased length of hospital stay (adjusted odds ratio [aOR] 10.1; 95% confidence interval [CI] 0.50\u201319.70), hospital charges (aOR USD 208,713; 95% CI 27,095\u2013390,330), and risk of death (aOR 17.17; 95% CI 5.88\u201350.07) in the AP-CE group. Secondary outcomes showed patients with AP-CE had a significantly increased risk of serious complications, particularly cardiac arrest (aOR 64.24; 95% CI 24.27\u2013170.02), and higher hospital resource utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with AP who develop CE face worse outcomes, including increased mortality risk, prolonged hospital stay, and greater resource utilization. Timely identification and effective management of CE in AP may reduce mortality and ease the health care burden associated with this neurological complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605241311405","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T14:08:38Z","timestamp":1738246118000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-7545","authenticated-orcid":false,"given":"Muhammad","family":"Shahzil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Penn State Health, Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammad Javaid","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Javaid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishali","family":"Moond","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Peter\u2019s University\/Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokturk","family":"Tepe","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, Detroit, MI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Saad","family":"Faisal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ali","family":"Khaqan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Kentucky, Lexington, KY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Kutait","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"bibr1-03000605241311405","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.068"},{"key":"bibr2-03000605241311405","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.043"},{"key":"bibr3-03000605241311405","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0365-8"},{"key":"bibr4-03000605241311405","first-page":"94","volume":"41","author":"Chen L","year":"2002","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"bibr5-03000605241311405","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.11.047"},{"key":"bibr6-03000605241311405","first-page":"257","volume":"10","author":"Zarnescu NO","year":"2015","journal-title":"Maedica 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