{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:57:05Z","timestamp":1793656625238,"version":"4.5.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prone ventilation improves lung function in patients with acute respiratory distress syndrome by enhancing oxygenation; however, managing enteral nutrition during prone ventilation is challenging due to body position changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the study was to assess the safety and efficacy of enteral nutrition during prone ventilation. A meta-analysis was conducted to evaluate the efficacy and safety of enteral nutrition in the prone position in critically ill ventilated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By searching databases such as PubMed, Embase, Cochrane Library, Web of Science, Cumulative Index of Nursing and Allied Health Literature, and WanFang Data, the relevant literature was retrieved from their inception to 24 December 2024. The Newcastle\u2013Ottawa Scale was used to evaluate article quality. Egger\u2019s test was used to check for publication bias, and Review Manager 5.4 was used to conduct the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 81 publications, five studies with a total sample size of 319 were included in this study. Enteral nutrition in the prone position, compared with that in the supine position, was associated with a lower energy achievement rate (mean difference: \u22120.88; 95% confidence interval: \u22121.83 to 0.06; P\u2009&lt;\u20090.00001), no significant difference in mortality (odds ratio: 1.11; 95% confidence interval: 0.65 to 1.88; P\u2009=\u20090.7), a greater incidence of ventilator-associated pneumonia (odds ratio: 2.11; 95% confidence interval: 1.12 to 3.96; P\u2009=\u20090.02), more frequent vomiting (odds ratio: 2.38; 95% confidence interval: 1.61 to 3.50; P\u2009&lt;\u20090.0001), a greater gastric residual volume (odds ratio: 2.72; 95% confidence interval: 1.47 to 5.03; P\u2009=\u20090.001), and increased interruptions in enteral nutrition (odds ratio: 4.75; 95% confidence interval: 2.22 to 10.17; P\u2009&lt;\u20090.0001). The Egger\u2019s test suggested no significant publication bias in the meta-analysis of mortality, gastric residual volume, adequate enteral nutrition achievement, and ventilator-associated pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A greater gastric residual volume, more frequent vomiting, and greater incidences of ventilator-associated pneumonia and enteral feeding interruptions are linked to enteral nutrition during prone ventilation. There was no statistically significant difference in mortality between the prone and supine positions. However, the prone position showed a slight trend toward reducing energy achievement rates, although this difference was not statistically significant.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registration number:<\/jats:bold>\n                      PROSPERO CRD: 42023441409.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251322358","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T13:57:07Z","timestamp":1743688627000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and efficacy of enteral nutrition during prone ventilation: A meta-analysis"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-5686","authenticated-orcid":false,"given":"Pan","family":"Jianzhen","sequence":"first","affiliation":[{"name":"Hunan Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Mei","sequence":"additional","affiliation":[{"name":"Hunan Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jianghong","sequence":"additional","affiliation":[{"name":"Hunan Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fei","sequence":"additional","affiliation":[{"name":"Hunan Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lili","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University First Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.10.131"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318247cd4f"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04271"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03552-2"},{"key":"e_1_3_8_6_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/PHM.0000000000001530","article-title":"The down side of prone positioning: the case of a coronavirus 2019 survivor","volume":"99","author":"Le MQ","year":"2020","unstructured":"Le MQ, Rosales R, Shapiro LT, et\u00a0al. 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