{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:14:46Z","timestamp":1781522086386,"version":"3.54.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy of weekly measurement of \u03b2-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in patients with unexplained recurrent miscarriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included patients with unexplained recurrent miscarriage whose serum \u03b2-human chorionic gonadotropin, estradiol, and progesterone levels were measured three or more times during early pregnancy. The patients were divided into two groups according to pregnancy outcomes. The \u0394\u03b2-human chorionic gonadotropin, \u0394estradiol, and \u0394progesterone levels of the two groups were compared, and the corresponding cutoff values were determined using receiver operating characteristic analyses for predicting pregnancy outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 140 patients were analyzed. From the 6th week to 10th week, the serum \u03b2-human chorionic gonadotropin and estradiol levels of the ongoing pregnancy group were significantly higher than those of the miscarriage group. The serum \u0394\u03b2-human chorionic gonadotropin levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.841 (95% confidence interval: 0.769\u20130.914) and diagnostic cutoff value of 30,633\u2009mIU\/mL. The \u0394estradiol levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.839 (95% confidence interval: 0.752\u20130.926) and a cutoff value of 45\u2009pg\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weekly remeasurement of serum \u03b2-human chorionic gonadotropin and estradiol may be useful for pregnancy risk assessment in patients with unexplained recurrent miscarriage in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251327478","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:31:54Z","timestamp":1745987514000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Weekly changes in serum\n                    <b>\u03b2<\/b>\n                    -human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in women with unexplained recurrent miscarriage"],"prefix":"10.1177","volume":"53","author":[{"given":"Ruide","family":"Su","sequence":"first","affiliation":[{"name":"Xiamen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiamen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Lu","sequence":"additional","affiliation":[{"name":"Xiamen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizhu","family":"Lin","sequence":"additional","affiliation":[{"name":"Xiamen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-0263","authenticated-orcid":false,"given":"Jian","family":"An","sequence":"additional","affiliation":[{"name":"Xiamen University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-F"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69204-0"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1005330"},{"key":"e_1_3_8_5_2","unstructured":"Speroff L Fritz MA. Recurrent early pregnancy loss. In: Clinical gynecologic endocrinology & infertility. 7th ed. Philadelphia PA: Lippincott Williams & Wilkins 2005; ch 28 P1069\u20131103."},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12480"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.2008"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.072"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-2002-z"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1261-4"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23559"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610857"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6438"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04158-w"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.11.020"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.04.048"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90185-8"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251327478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251327478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251327478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:14Z","timestamp":1777459634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251327478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/03000605251327478"],"URL":"https:\/\/doi.org\/10.1177\/03000605251327478","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"article-number":"03000605251327478"}}