{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:15:42Z","timestamp":1782796542725,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>White spot lesion formation around orthodontic brackets is a major complication associated with fixed orthodontic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aimed to evaluate the current evidence regarding the differences in white spot lesion formation between self-ligating and conventional ligating brackets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eleven bibliographic databases were searched until January 2025. This review covered parallel-group and split-mouth randomized controlled trials, controlled clinical trials, and cross-sectional studies that investigated the differences in white spot lesion formation between self-ligating and conventional ligating brackets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three randomized controlled trials, one controlled clinical trial, and one cross-sectional study were included in this systematic review. Among these, three studies were classified as having a low risk of bias. Four of the five included studies showed no statistically significant difference in white spot lesion formation between the two types of bracket systems (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There are no potential differences in white spot lesion formation between self-ligating and conventional ligating bracket systems. However, orthodontists must be aware of the other factors affecting white spot lesion formation, with oral hygiene being the most critical factor.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Registration:<\/jats:bold>\n                      The protocol was registered in the PROSPERO database (CRD42022353478) on 25 August 2022.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251328608","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T15:44:47Z","timestamp":1744386287000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["White spot lesion in self-ligating versus conventional ligating bracket systems: A systematic review"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6542-3040","authenticated-orcid":false,"given":"Mohammad I","family":"Idris","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad S","family":"Burhan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Y","family":"Hajeer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria"},{"name":"Department of Orthodontics, School of Dentistry, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad M","family":"Alhamwi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fehmie R","family":"Nawaya","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, Faculty of Dentistry, Syrian Private University, Damascus, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1240-3"},{"key":"e_1_3_10_3_2","first-page":"e65679","article-title":"White spot lesions in fixed orthodontics: a literature review on etiology, prevention, and treatment","volume":"16","author":"Al-Blaihed D","year":"2024","unstructured":"Al-Blaihed D, El Meligy O, Baghlaf K, et\u00a0al. White spot lesions in fixed orthodontics: a literature review on etiology, prevention, and treatment. Cureus 2024; 16: e65679.","journal-title":"Cureus"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198738268.001.0001"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.2319\/051710-262.1"},{"key":"e_1_3_10_6_2","first-page":"Zc149","article-title":"Assessment of white spot lesions and in-vivo evaluation of the effect of CPP-ACP on white spot lesions in permanent molars of children","volume":"10","author":"Munjal D","year":"2016","unstructured":"Munjal D, Garg S, Dhindsa A, et\u00a0al. Assessment of white spot lesions and in-vivo evaluation of the effect of CPP-ACP on white spot lesions in permanent molars of children. 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