{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:57:52Z","timestamp":1777726672088,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Health Guidance Project of Xiamen Science and Technology Bureau","award":["No.3502Z20209216"],"award-info":[{"award-number":["No.3502Z20209216"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"\n Objective<\/jats:title>\n \n To examine the impact of the 13-valent pneumococcal vaccine on\n Streptococcus pneumoniae<\/jats:italic>\n serotypes and antibiotic susceptibility in children to inform the prevention and treatment of\n S. pneumoniae<\/jats:italic>\n infections.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed and compared\n S. pneumoniae<\/jats:italic>\n serotypes and antibiotic susceptibility between children vaccinated with 13-valent pneumococcal vaccine (vaccinated group) and unvaccinated children (control group).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We collected 167\n S. pneumoniae<\/jats:italic>\n strains that met the study requirements from 60 children (35.92%) in the vaccinated group and 107 (64.08%) children in the control group. The antibiotic susceptibility test revealed no significant difference in susceptibility to oral penicillin (a \u03b2-lactam) or penicillin injection between the two groups. Of the third-generation cephalosporins, susceptibility to ceftriaxone and cefotaxime differed significantly among children with meningitis between the two groups (\n P<\/jats:italic>\n \u2009<\u20090.05) but not among children without meningitis. In total, 167 strains were susceptible to vancomycin. Neither of the groups were susceptible to erythromycin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The majority of the\n S. pneumoniae<\/jats:italic>\n serotypes isolated from children in Xiamen were covered by the 13-valent pneumococcal vaccine. The isolated\n S. pneumoniae<\/jats:italic>\n strains were highly resistant to erythromycin and tetracycline but remained susceptible to vancomycin. Children vaccinated with the 13-valent pneumococcal vaccine may benefit from parenteral third-generation cephalosporins after developing pneumococcal meningitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/03000605251336064","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T20:12:47Z","timestamp":1746043967000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of the 13-valent pneumococcal vaccine on\n Streptococcus pneumoniae<\/i>\n serotypes and antibiotic susceptibility in children"],"prefix":"10.1177","volume":"53","author":[{"given":"Zhang","family":"Shengxin","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-8388","authenticated-orcid":false,"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Huaying","sequence":"additional","affiliation":[{"name":"Emergency Department, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-2637","authenticated-orcid":false,"given":"Lou","family":"Qing","sequence":"additional","affiliation":[{"name":"Emergency Department, Xiamen Children\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_3_9_2_2","first-page":"1601","article-title":"Interpretation of expert consensus for diagnosis, treatment and prevention of pneumococcal diseases in children","volume":"36","author":"Bao YM","year":"2021","unstructured":"Bao YM, Zheng YJ, Yang YH. Interpretation of expert consensus for diagnosis, treatment and prevention of pneumococcal diseases in children. Chin J Appl Clin Pediatr 2021; 36: 1601\u20131604.","journal-title":"Chin J Appl Clin Pediatr"},{"key":"e_1_3_9_3_2","first-page":"1315","article-title":"Vaccine and Immunology Branch of the Chinese Preventive Medicine Association. Expert consensus on immunoprophylaxis of pneumococcal disease (2020 version)","volume":"54","author":"Chinese Preventive Medicine Association","year":"2020","unstructured":"Chinese Preventive Medicine Association. Vaccine and Immunology Branch of the Chinese Preventive Medicine Association. Expert consensus on immunoprophylaxis of pneumococcal disease (2020 version). Zhonghua Yu Fang Yi Xue Za Zhi 2020; 54: 1315\u20131363.","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_9_5_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing; twentieth informational supplement. CLSI Document M100\u2013S20. Wayne PA. Clinical and Laboratory Standards Institute. 2010."},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00024-15"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-019-00198-9"},{"key":"e_1_3_9_8_2","first-page":"565","article-title":"Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children","volume":"26","author":"Lin WJ","year":"2022","unstructured":"Lin WJ, Shao XJ, Zhang J, et\u00a0al. Effect of 13-valent pneumococcal conjugate vaccine on serotypes and antibiotic-resistance of streptococcus pneumoniae in children. Chin J Dis Control Prev 2022; 26: 565\u2013570.","journal-title":"Chin J Dis Control Prev"},{"key":"e_1_3_9_9_2","first-page":"49","article-title":"Progress on the pathogenicity of non-vaccine type Streptococcus pneumoniae in children","volume":"51","author":"Du M","year":"2024","unstructured":"Du M, Han ZY. Progress on the pathogenicity of non-vaccine type Streptococcus pneumoniae in children. Int J Pediatr 2024; 51: 49\u201353.","journal-title":"Int J Pediatr"},{"key":"e_1_3_9_10_2","first-page":"485","article-title":"Chinese Experts\u2019 Consensus Statement on Diagnosis, Treatment, and Prevention of Pneumococcal Diseases in Children","volume":"35","author":"China National Clinical Research Center for Respiratory Diseases, National Center for Children\u2019s Health, Group of Respirology Chinese Pediatric Society","year":"2020","unstructured":"China National Clinical Research Center for Respiratory Diseases, National Center for Children\u2019s Health, Group of Respirology Chinese Pediatric Societyet\u00a0al. Chinese Experts\u2019 Consensus Statement on Diagnosis, Treatment, and Prevention of Pneumococcal Diseases in Children. Chin J Appl Clin Pediatr 2020; 35: 485\u2013505.","journal-title":"Chin J Appl Clin Pediatr"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1985353"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03759-22"},{"key":"e_1_3_9_13_2","first-page":"521","article-title":"Evolution of antibiotic resistance of Streptococcus pneumoniae in children","volume":"35","author":"Shi W","year":"2020","unstructured":"Shi W, Gao W, Yao KH. Evolution of antibiotic resistance of Streptococcus pneumoniae in children. Chin J Appl Clin Pediatr 2020; 35: 521\u2013525.","journal-title":"Chin J Appl Clin Pediatr"},{"key":"e_1_3_9_14_2","first-page":"78","article-title":"Clinical characteristics, serotypes and drug resistance analysis of 265 clinical isolates of Streptococcus pneumoniae","volume":"37","author":"Huang LJ","year":"2015","unstructured":"Huang LJ, Yuan YT, Wang YF, et\u00a0al. Clinical characteristics, serotypes and drug resistance analysis of 265 clinical isolates of Streptococcus pneumoniae. Fujian Med J 2015; 37: 78\u201381.","journal-title":"Fujian Med J"},{"key":"e_1_3_9_15_2","first-page":"582","article-title":"Clinical characteristics and antimicrobial resistance of pneumococcal infections from 9 children\u2019s hospitals in 2016","volume":"56","author":"Fang C","year":"2018","unstructured":"Fang C, Chen XJ, Zhou MM, et\u00a0al. Clinical characteristics and antimicrobial resistance of pneumococcal infections from 9 children\u2019s hospitals in 2016. Chin J Pediatr 2018; 56: 582\u2013586.","journal-title":"Chin J Pediatr"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718712115"},{"key":"e_1_3_9_17_2","first-page":"1","article-title":"CHINET surveillance of bacterial resistance in China: 2018 report","volume":"20","author":"Hu FP","year":"2020","unstructured":"Hu FP, Guo Y, Zhu DM, et\u00a0al. CHINET surveillance of bacterial resistance in China: 2018 report. Chin J Infect Chemother 2020; 20: 1\u201310.","journal-title":"Chin J Infect Chemother"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001248"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251336064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251336064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251336064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:24Z","timestamp":1777459644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251336064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/03000605251336064"],"URL":"https:\/\/doi.org\/10.1177\/03000605251336064","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"article-number":"03000605251336064"}}