{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:58:43Z","timestamp":1793134723536,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the clinical and serological features of autoimmunity with chronic hepatitis C virus infection before and after direct-acting antiviral therapy and assess their relation to treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was performed in adult patients aged \u226518 years who had chronic hepatitis C virus infection, as confirmed by polymerase chain reaction, and were eligible for direct-acting antiviral therapy. Patients with rheumatological disease prior to the onset of hepatitis C virus infection, decompensated cirrhosis, or hepatocellular carcinoma were excluded. All patients were treated with sofosbuvir (400\u2009mg once daily) plus daclatasvir (60\u2009mg once daily) for 3 months. Patients were assessed before and 12 weeks after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety patients completed the follow-up (66.7% females, 33.3% males, mean age: 49.2\u2009\u00b1\u200912.3 years); 85.55% of them had immune-mediated manifestations prior to direct-acting antiviral therapy. In patients with sustained virologic response, autoimmune manifestations persisted in 66 of the 71 (92.9%) patients with an observable rise in posttreatment erythrocyte sedimentation rate and C-reactive protein level (p\u2009&gt;\u20090.01). The predictors of persistence of autoimmune manifestation were age \u226549 years (p\u2009=\u20090.009), female sex (p\u2009=\u20090.026), and tobacco use (p\u2009=\u20090.043).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Direct-acting antiviral drugs were not associated with a significant short-term change in the prevalence of autoimmune manifestations in patients who had hepatitis C virus infection with sustained virologic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251339135","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:36:20Z","timestamp":1747726580000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune manifestations and direct-acting antiviral drugs in Egyptian patients with hepatitis C virus infection: A cohort study"],"prefix":"10.1177","volume":"53","author":[{"given":"Hesham I","family":"Elmakhzangy","sequence":"first","affiliation":[{"name":"Department of Endemic Diseases and Hepato-Gastroenterology, School of Medicine\u2013Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai A","family":"Rabie","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation\u2013Ministry of Health and Population, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina MR","family":"Bahgat","sequence":"additional","affiliation":[{"name":"Department of Clinical &amp; Chemical Pathology, School of Medicine\u2013Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa HS","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Rehabilitation, School of Medicine\u2013Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed ET","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Endemic Diseases and Hepato-Gastroenterology, School of Medicine\u2013Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-7687","authenticated-orcid":false,"given":"Reem Hamdy A","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Rehabilitation, School of Medicine\u2013Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S113681"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a036913"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i11.2962"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203883"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1463-x"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1405"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.001"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.4172\/1758-4272.1000187"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.033"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2011.10.031"},{"key":"e_1_3_7_13_2","unstructured":"World Health Organization (WHO). Hepatitis C fact sheet https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c (2023 accessed 23 March 2023)."},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1912628"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13272"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-020-04639-x"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.07.021"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.21608\/mjvh.2021.158275"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2017.09.004"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43166-020-00023-4"},{"key":"e_1_3_7_21_2","first-page":"168","article-title":"Clinical characteristics of HCV in Egyptian patients","volume":"6","author":"Naga M","year":"2019","unstructured":"Naga M, Esmat E, Ahmed H, et\u00a0al. Clinical characteristics of HCV in Egyptian patients. 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