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Herein, we present the case of an otherwise generally healthy woman in her early 30s who presented to the oral medicine clinic with a chief complaint of multiple missing teeth. Family history revealed that her sister and brother had the same complaint. Panoramic and cone-beam computed tomography radiographic findings revealed the presence of multiple impacted supernumerary teeth in both jaws. Multiple radiopacities and frontal sinus osteoma were noted. The radiographic features were suggestive of Gardner syndrome. An endoscopy was requested, which turned out negative for any polyps, with a recommendation to repeat endoscopy after 10 years. This is because the cranial osteoma might precede the gastrointestinal polyposis. A comprehensive treatment plan was performed by a team of dentists from multiple specialties (oral medicine, oral radiology, orthodontics, prosthodontics, and oral surgery) to ensure optimal outcomes for the patient. Thus, it is essential for dentists to identify and explore any atypical findings that may arise during clinical examination.<\/jats:p>","DOI":"10.1177\/03000605251339146","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T10:18:21Z","timestamp":1750069101000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial multiple impacted supernumerary teeth: Case report"],"prefix":"10.1177","volume":"53","author":[{"given":"Loulwah K","family":"Alothman","sequence":"first","affiliation":[{"name":"Oral Medicine and Diagnostic Science Department, College of Dentistry, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-3966","authenticated-orcid":false,"given":"Azizah F","family":"Bin Mubayrik","sequence":"additional","affiliation":[{"name":"Oral Medicine and Diagnostic Science Department, College of Dentistry, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Alshawaf","sequence":"additional","affiliation":[{"name":"Oral Medicine and Diagnostic Science Department, College of Dentistry, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Alfotawi","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department, College of Dentistry, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz S","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Prosthetic Dental Sciences Department, College of Dentistry, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"22","article-title":"Supernumerary teeth: literature review","volume":"47","author":"Rao PV","year":"2001","unstructured":"Rao PV, Chidzonga MM. 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