{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:53:59Z","timestamp":1791910439272,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute lung injury is a fatal complication triggered by sepsis, characterized by widespread inflammation and weakening of the alveolar epithelium. Irisin has been reported to exert anti-inflammatory effects, which are produced by the cleavage of fibronectin type III domain-containing protein 5 in skeletal muscle. Here, we investigated the potential of irisin in preventing acute lung injury by protecting the alveolar epithelium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sepsis-related acute lung injury model was established by a cecal ligation and puncture model in C57\/BL6N mice. Lung histology was assessed using hematoxylin and eosin and Masson staining. Ferroptosis-related proteins and genes were quantified via western blot and quantitative polymerase chain reaction, respectively, whereas cytokine levels were measured using enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histological analysis revealed lung injury in the cecal ligation and puncture group, alongside elevated levels of cytokines such as IL-1\u03b2, IL-18, and TNF-\u03b1 compared with controls. Treatment with irisin mitigated sepsis-induced lung damage and reduced oxidative stress, as indicated by reactive oxygen species and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      levels. Furthermore, irisin pretreatment inhibited the upregulation of ferroptosis-related genes (\n                      <jats:italic toggle=\"yes\">Acsl4<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Ptgs2<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Hspa5<\/jats:italic>\n                      ) as well as ACSL4, COX-2, and p-AMPK expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that irisin treatment is associated with reduced ferroptosis and inflammation in sepsis-induced acute lung injury. Irisin emerges as a promising candidate for acute lung injury therapy induced by sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251340338","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:20:04Z","timestamp":1747981204000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The therapeutic potential of irisin in alleviating acute lung injury via inflammation and ferroptosis modulation"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5250-2789","authenticated-orcid":false,"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Huaiyin Maternal and Child Health Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Huai\u2019an Fifth People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Huai\u2019an Fifth People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Huai\u2019an Fifth People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Huai\u2019an Fifth People\u2019s Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huai\u2019an Fifth People\u2019s Hospital, Huai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0756-5"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.779620"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152997"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683996"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0005-7"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06292-z"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00735-4"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2021.1072"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00205-0"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101679"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031118"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1106529"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.09.025"},{"key":"e_1_3_6_16_2","doi-asserted-by":"crossref","first-page":"e0158038","DOI":"10.1371\/journal.pone.0158038","article-title":"Protective effect of irisin on atherosclerosis via suppressing oxidized low density lipoprotein induced vascular inflammation and endothelial dysfunction","volume":"11","author":"Zhang Y","year":"2016","unstructured":"Zhang Y, Mu Q, Zhou Z, et\u00a0al. 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