{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:41:32Z","timestamp":1793227292307,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Xingwu Xie","award":["Guiding Research Project of Shiyan Science and Tec"],"award-info":[{"award-number":["Guiding Research Project of Shiyan Science and Tec"]}]},{"name":"Yanxi Xiong","award":["Guiding Research Project of Hubei Provincial Healt"],"award-info":[{"award-number":["Guiding Research Project of Hubei Provincial Healt"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the effects of chronic alcohol consumption on brain functional connectivity using resting-state functional magnetic resonance imaging and degree centrality analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross-sectional study, with participants including 23 light-to-moderate drinkers, 25 heavy drinkers, and 29 healthy controls aged 40\u201360 years. Degree centrality analysis was used to compare brain function differences among groups, and the relationships between degree centrality values, cognitive scores, and drinking behaviors were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Heavy drinkers showed significantly reduced degree centrality values in the left inferior temporal gyrus compared with healthy controls as well as in the left inferior temporal gyrus and left middle occipital gyrus compared with light-to-moderate drinkers. Degree centrality values in the left inferior temporal gyrus and left middle occipital gyrus were negatively correlated with drinking frequency and Michigan Alcoholism Screening Test scores but were positively correlated with cognitive scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Heavy drinking significantly disrupts brain functional networks. These findings suggest a potential link between cognitive function and drinking behavior, which may inform future research on early interventions aimed at protecting brain function in chronic alcohol users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251345891","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:31:33Z","timestamp":1750818693000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in resting-state brain function in chronic alcohol users based on degree centrality"],"prefix":"10.1177","volume":"53","author":[{"given":"Guangping","family":"Su","sequence":"first","affiliation":[{"name":"Department of Radiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P. R. China"},{"name":"Guangping Su and Zhezi Wang are both considered co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhezi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P. R. China"},{"name":"Guangping Su and Zhezi Wang are both considered co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P. R. China"},{"name":"Guangping Su and Zhezi Wang are both considered co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P. R. 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