{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:58:57Z","timestamp":1777726737840,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Mixed neuroendocrine non-neuroendocrine neoplasms of the gastrointestinal tract are rare, with only a few cases documented in the literature. In particular, there are no reports of a rectal mixed neuroendocrine non-neuroendocrine neoplasm with regional lymph node metastasis of the neuroendocrine tumor component. Here, we present the case of a man in his early 70s with an incidental finding of multiple colonic polyps during a routine colonoscopy, including a 0.9-cm sessile polyp in the rectum. Repeat colonoscopy was performed for endoscopic mucosal resection. Histopathological examination revealed a biphasic tumor comprising a well-differentiated adenocarcinoma and a grade 1 neuroendocrine tumor, leading to a diagnosis of rectal mixed neuroendocrine non-neuroendocrine neoplasm. Because the adenocarcinoma component had invaded the submucosa and involved the resection margin, an ultralow anterior resection was performed. Notably, postoperative pathological analysis revealed metastasis of the neuroendocrine tumor component to a regional lymph node, an unusual finding not previously reported in the literature. Despite this, the patient remained recurrence-free for 2 years without adjuvant therapy. To the best of our knowledge, this is the first such case to be reported in the literature. Given the limited understanding of mixed neuroendocrine non-neuroendocrine neoplasms, particularly cases with low-grade neuroendocrine components, further case accumulation is necessary to develop standardized treatment guidelines.<\/jats:p>","DOI":"10.1177\/03000605251345907","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T07:34:52Z","timestamp":1749108892000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymph node metastasis of grade 1 neuroendocrine tumor from rectal mixed neuroendocrine non-neuroendocrine neoplasm: A case report"],"prefix":"10.1177","volume":"53","author":[{"given":"Taek-Gu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-3779","authenticated-orcid":false,"given":"Chang Gok","family":"Woo","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-4649","authenticated-orcid":false,"given":"Seung-Myoung","family":"Son","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-72830-4_18"},{"key":"e_1_3_7_4_2","first-page":"219","article-title":"Management of MANEC of the colon and rectum: a comprehensive review of the literature","volume":"9","author":"Paspala A","year":"2018","unstructured":"Paspala A, Machairas N, Prodromidou A, et\u00a0al. Management of MANEC of the colon and rectum: a comprehensive review of the literature. 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Successful treatment of a mixed neuroendocrine-nonneuroendocrine neoplasm of the colon with metastases to the thyroid gland and liver. Case Rep Otolaryngol 2020; 2020: 5927610.","journal-title":"Case Rep Otolaryngol"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.08.054"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.183"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4460"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-021-01420-8"},{"key":"e_1_3_7_18_2","first-page":"243","article-title":"Mixed neuroendocrine-non-neuroendocrine neoplasms of the right colon: a case report","volume":"40","author":"Barkaoui ZE","year":"2021","unstructured":"Barkaoui ZE, Najih M, Mehdi AE, et\u00a0al. Mixed neuroendocrine-non-neuroendocrine neoplasms of the right colon: a case report. Pan Afr Med J 2021; 40: 243.","journal-title":"Pan Afr Med J"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.934396"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/10732748231160992"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.4293\/CRSLS.2023.00045"},{"key":"e_1_3_7_22_2","first-page":"261","article-title":"[A case report of rectal MiNEN surgical resection]","volume":"50","author":"Owada Y","year":"2023","unstructured":"Owada Y, Tachibana T, Tokuhara K, et\u00a0al. [A case report of rectal MiNEN surgical resection]. Gan To Kagaku Ryoho 2023; 50: 261\u2013263.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-023-02954-6"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.32677\/ijcr.v9i9.4160"},{"key":"e_1_3_7_25_2","first-page":"1477","article-title":"[A case report of rectal MiNEN laparoscopic resection]","volume":"50","author":"Kokubo S","year":"2023","unstructured":"Kokubo S, Fujita S, Sugawara D, et\u00a0al. [A case report of rectal MiNEN laparoscopic resection]. 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