{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:07:59Z","timestamp":1792858079763,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have shown that soluble growth-stimulated expression gene 2 protein (sST2) plays a significant role in the progression of maintenance hemodialysis. However, the relationship between sST2 and cardiovascular events in maintenance hemodialysis patients remains largely understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study systematically searched PubMed, Wanfang, and other Chinese and English databases for all published studies on sST2 in maintenance hemodialysis. Relevant literature meeting the requirements was screened, and relevant data were extracted accordingly. The Newcastle\u2013Ottawa Scale was used to evaluate the quality of the selected studies. Publication bias was assessed via funnel plots and Egger\u2019s test. A meta-analysis was performed using either a random-effects or fixed-effects model, as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10 high-quality studies were included in this study, with no significant publication bias. The meta-analysis revealed that sST2 level was associated with the incidence of cardiovascular events in maintenance hemodialysis patients (mean difference\u2009=\u200918.89, 95% confidence interval: 13.93\u201323.84; p\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.001). Moreover, elevated sST2 levels were correlated with a higher risk of cardiovascular events (odds ratio\u2009=\u20092.89, 95% confidence interval: 1.71\u20134.89; p\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sST2 may serve as a predictive biomarker for cardiovascular events in maintenance hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251345954","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:31:33Z","timestamp":1750818693000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of sST2 with cardiovascular disease in maintenance hemodialysis patients: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"53","author":[{"given":"Ze","family":"Zhang","sequence":"first","affiliation":[{"name":"Hubei University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hubei University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3997-2759","authenticated-orcid":false,"given":"Huaqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.6817"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30508-6"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac218"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2019.11.001"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000479250"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2018.03.001"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/126049"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_3_6_10_2","first-page":"497","article-title":"SST2 in maintenance hemodialysis elderly patients with heart failure condition assessment and prediction effect","volume":"40","author":"Gong J","year":"2021","unstructured":"Gong J, Li FW, Xie MS. SST2 in maintenance hemodialysis elderly patients with heart failure condition assessment and prediction effect. Journal of Hubei University of Medicine 2021; 40: 497\u2013500.","journal-title":"Journal of Hubei University of Medicine"},{"key":"e_1_3_6_11_2","first-page":"48","article-title":"Serum sST2 protein and maintenance hemodialysis patients with cardiovascular disease and the correlation analysis of overall prognosis","volume":"30","author":"He J","year":"2018","unstructured":"He J, Qin KW. Serum sST2 protein and maintenance hemodialysis patients with cardiovascular disease and the correlation analysis of overall prognosis. PLA Medical Journal 2018; 30: 48\u201352.","journal-title":"PLA Medical Journal"},{"key":"e_1_3_6_12_2","first-page":"71","article-title":"Correlation analysis of serum sST2 and NT-proBNP levels with heart failure in hemodialysis patients","volume":"28","author":"Lin S","year":"2021","unstructured":"Lin S, Wang GH. Correlation analysis of serum sST2 and NT-proBNP levels with heart failure in hemodialysis patients. Marker Immunoassay and Clinic 2021; 28: 71\u201375.","journal-title":"Marker Immunoassay and Clinic"},{"key":"e_1_3_6_13_2","first-page":"49","article-title":"Relationship between serum sST2, TN-C levels and cardiovascular events in patients with maintenance hemodialysis","volume":"60","author":"Gao ZY","year":"2020","unstructured":"Gao ZY, Ma Y, Zhu WJ. Relationship between serum sST2, TN-C levels and cardiovascular events in patients with maintenance hemodialysis. Shandong Medicine 2020; 60: 49\u201352.","journal-title":"Shandong Medicine"},{"key":"e_1_3_6_14_2","first-page":"376","article-title":"Relationship between serum soluble growth stimulating gene expression protein 2, tenascin C levels and cardiovascular events in patients with maintenance hemodialysis","volume":"19","author":"Yang J","year":"2020","unstructured":"Yang J, Wan CY, Li T, et\u00a0al. Relationship between serum soluble growth stimulating gene expression protein 2, tenascin C levels and cardiovascular events in patients with maintenance hemodialysis. Blood Purification in China 2020; 19: 376\u2013380.","journal-title":"Blood Purification in China"},{"key":"e_1_3_6_15_2","first-page":"295","article-title":"Association of serum growth stimulating expression gene 2 protein and lipoprotein-associated phospholipase A2 with cardiovascular events in maintenance hemodialysis patients","volume":"17","author":"Gao J","year":"2022","unstructured":"Gao J, Wang DQ, Zhou YH, et\u00a0al. Association of serum growth stimulating expression gene 2 protein and lipoprotein-associated phospholipase A2 with cardiovascular events in maintenance hemodialysis patients. 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