{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:06:51Z","timestamp":1789787211013,"version":"4.0.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the knowledge innovation project of Wuhan Science and Technology Bureau","award":["2022020801020562"],"award-info":[{"award-number":["2022020801020562"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to explore the effect of sphingosine-1-phosphate on vascular homeostasis in the myocardium of diabetic mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bioinformatics analyses were performed to analyze the targets and function of sphingosine-1-phosphate in diabetes. C57BL\/6 mice were used to establish diabetic models and treated with sphingosine-1-phosphate. Pathological examination was used to evaluate the damage to the myocardium. Immunohistochemistry and western blot analyses were used to examine the expression of molecules involved in vascular function and sphingosine-1-phosphate receptors. Endothelial nitric oxide synthase level was detected via enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multiple Gene Ontology entries of sphingosine-1-phosphate were associated with vascular homeostasis. Blood glucose level, food intake, and water intake increased and body weight decreased in diabetic mice, whereas these changes were relieved in the sphingosine-1-phosphate group. Sphingosine-1-phosphate alleviated the myocardial injury and restored the expression levels of vascular endothelial-cadherin, vascular endothelial growth factor, and CD31 in the myocardium of diabetic mice to some extent. The serum level of endothelial nitric oxide synthase increased in the sphingosine-1-phosphate group. Additionally, sphingosine-1-phosphate was demonstrated to act on its receptors S1PR1, S1PR2, and S1PR3, which were downregulated in the myocardium of diabetic mice and significantly upregulated after sphingosine-1-phosphate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sphingosine-1-phosphate may restore myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in diabetic mice, suggesting sphingosine-1-phosphate\/sphingosine-1-phosphate receptors as potential therapeutic targets for diabetic myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251346591","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:31:33Z","timestamp":1750818693000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice"],"prefix":"10.1177","volume":"53","author":[{"given":"Guozhu","family":"Jin","sequence":"first","affiliation":[{"name":"Wuhan Fourth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Fourth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"Wuhan Fourth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6081-7640","authenticated-orcid":false,"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Wuhan Fourth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0278-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2018-0045"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X18666220617121144"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-023-01384-3"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01655-5"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz037"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-022-2600-x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24044018"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2021.106874"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246273"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.307049"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P089409"},{"key":"e_1_3_5_15_2","first-page":"213","article-title":"Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells","volume":"37","author":"Qiu Y","year":"2022","unstructured":"Qiu Y, Shen J, Jiang W, et\u00a0al. 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