{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:45:26Z","timestamp":1793580326037,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Stenotrophomonas maltophilia<\/jats:italic>\n                    is a multidrug-resistant gram-negative pathogen associated with high morbidity and mortality, especially in immunocompromised patients. Its resistance mechanisms include aminoglycoside-modifying enzymes,\n                    <jats:italic toggle=\"yes\">qnrB<\/jats:italic>\n                    -like quinolone resistance genes, multidrug efflux pumps, and \u03b2-lactamases (L1 and L2). With the increasing incidence of\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    infections, effective treatment strategies are urgently needed to combat its growing resistance. We present the case of a preterm male neonate, born at 30 weeks of gestation, who developed respiratory distress requiring mechanical ventilation. Empiric antibiotics were initiated but failed to prevent clinical deterioration. Respiratory cultures confirmed that multidrug-resistant\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    is resistant to standard therapies, necessitating a novel dual regimen of ceftazidime\u2013avibactam and aztreonam. This combination therapy was administered for 14 days, leading to microbiological clearance and clinical improvement, allowing successful extubation. To the best of our knowledge, this is the first documented case of ceftazidime\u2013avibactam and aztreonam successfully treating multidrug-resistant\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    infection in a preterm infant. This case underscores the potential of ceftazidime\u2013avibactam and aztreonam as a viable therapeutic option for multidrug-resistant\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    infections in neonates. Further studies are warranted to validate its safety and efficacy in similar cases.\n                  <\/jats:p>","DOI":"10.1177\/03000605251353486","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T03:45:25Z","timestamp":1766461525000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful dual therapy of aztreonam and ceftazidime\u2013avibactam for multidrug-resistant\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    infection in a preterm neonate: A life-saving approach"],"prefix":"10.1177","volume":"53","author":[{"given":"Abdulrahman O","family":"Alghamdi","sequence":"first","affiliation":[{"name":"Pediatric Department, Infectious Disease Division, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulelah S","family":"Algethami","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Salman Specialized, National Guard Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed S","family":"Aljuaeed","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Salman Specialized, National Guard Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal M","family":"Alkhammash","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal M","family":"Almalki","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Taif University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan A","family":"Alharthi","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejood M","family":"Aljaed","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma AS","family":"Abosabie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A","family":"Abosabie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-3838","authenticated-orcid":false,"given":"Naglaa M","family":"Kamal","sequence":"additional","affiliation":[{"name":"Pediatric Department, Kasralainy Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_9_2_2","volume-title":"Harrison\u2019s principles of internal medicine","author":"Loscalzo J","year":"2022","unstructured":"Loscalzo J, Fauci A, Kasper D, et\u00a0al. Harrison\u2019s principles of internal medicine. 21st ed. New York: McGraw Hill, 2022.","edition":"21"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02276"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70083-0"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0709-5"},{"key":"e_1_3_9_6_2","unstructured":"World Health Organization. Public health importance of antimicrobial resistance https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/326454\/WHO-HIS-SDS-2018.56-eng.pdf (2018 accessed 23 November 2024)."},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.84"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.007"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10101226"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv456"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-19"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00264-16"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-11"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-4-r74"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01485-07"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00893"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00777-17"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0725-1"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1013"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.5.16375"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-021-02108-2"},{"key":"e_1_3_9_23_2","first-page":"e00297","article-title":"Activity of aztreonam in combination with avibactam, clavulanate, relebactam, and vaborbactam against multidrug-resistant Stenotrophomonas maltophilia","volume":"64","author":"Biagi M","year":"2020","unstructured":"Biagi M, Lamm D, Meyer K, et\u00a0al. Activity of aztreonam in combination with avibactam, clavulanate, relebactam, and vaborbactam against multidrug-resistant Stenotrophomonas maltophilia. 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