{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:59:48Z","timestamp":1777726788112,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the association of TLR3 single-nucleotide polymorphisms 1337\u2009C\/T (rs3775290) and 1234\u2009C\/T (rs3775291) with the risk of chronic hepatitis B virus infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study enrolled 136 participants (66 patients with chronic hepatitis B virus infection (cases) and 70 healthy controls). TLR3 polymorphisms were genotyped using polymerase chain reaction\u2013restriction fragment length polymorphism. Demographic\/clinical data were collected via standardized questionnaires and analyzed using Statistical Package for Social Sciences (significance level: p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For TLR3 1337\u2009C\/T polymorphism, the CT genotype prevalence was significantly higher in cases (47.0%) than in controls (31.4%) (odds ratio\u2009=\u20090.42, 95% confidence interval: 0.20\u20130.87, p\u2009=\u20090.0187), while the CC genotype demonstrated protective effects (39.4% in cases vs. 62.9% in controls; odds ratio\u2009=\u20090.26, 95% confidence interval: 0.07\u20130.94, p\u2009=\u20090.0314). The C allele frequency showed significant between-group differences (odds ratio\u2009=\u20090.46, p\u2009=\u20090.0044). No associations were observed for 1234\u2009C\/T single-nucleotide polymorphism (p\u2009=\u20091.0). Biochemical analysis revealed significantly elevated alanine aminotransferase (p\u2009=\u20090.0044) and aspartate aminotransferase (p\u2009&lt;\u20090.0001) levels in cases than in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regarding TLR3 1337\u2009C\/T single-nucleotide polymorphism, the CT genotype increases the risk of chronic hepatitis B virus infection (odds ratio\u2009=\u20090.42), while the CC genotype demonstrates protective effects (odds ratio\u2009=\u20090.26) in Sudanese populations, suggesting its utility as a therapeutic target and prognostic marker. No 1234\u2009C\/T associations were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251358062","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:43:32Z","timestamp":1753350212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of TLR3 1337C\/T and 1234C\/T polymorphisms with chronic hepatitis B virus infection in Sudanese patients: A case\u2013control study"],"prefix":"10.1177","volume":"53","author":[{"given":"Khalid","family":"Elyass","sequence":"first","affiliation":[{"name":"Faculty of Medical Laboratory Sciences, Omdurman Islamic University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-0334","authenticated-orcid":false,"given":"Najem Aldin M","family":"Osman","sequence":"additional","affiliation":[{"name":"Faculty of Medical Laboratory Sciences, Omdurman Islamic 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