{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:59:57Z","timestamp":1777726797243,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Enterovirus D68 mainly causes respiratory tract infections, with children being the main infected population and most adults experiencing latent infections. This report presents the cases of two older patients with enterovirus D68 pneumonia. Both of them were diagnosed using next-generation sequencing, and one of them died of mediastinal emphysema despite undergoing various treatments. This report also reviewed the biological characteristics and epidemiological features of enterovirus D68 as well as the clinical diagnosis and treatment of the viral pneumonia. Currently, there are no specific antiviral drugs or vaccines, and the treatment mainly focuses on symptomatic support and anti-inflammatory therapy. Although there exists certain understanding of enterovirus D68 pneumonia, there are challenges in aspects such as a deeper understanding of the viral mechanism, development of drugs and vaccines, and optimization of diagnosis and treatment methods. Strengthening monitoring and health education is crucial for preventing and controlling the spread of this infection.<\/jats:p>","DOI":"10.1177\/03000605251359612","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:01:47Z","timestamp":1753711307000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Enterovirus D68 pneumonia in two older patients: A case report and literature review"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-2336","authenticated-orcid":false,"given":"Weizhong","family":"Jin","sequence":"first","affiliation":[{"name":"Shanghai Public Health Clinical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changcheng","family":"Shi","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences &amp; Peking Union Medical College, China"},{"name":"Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Affiliated Hangzhou First People\u2019s Hospital, Westlake University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2024.1328457"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261962"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00543-5"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0567-8"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02418-15"},{"key":"e_1_3_7_7_2","doi-asserted-by":"crossref","first-page":"e000437","DOI":"10.1136\/bmjresp-2019-000437","article-title":"Molecular epidemiological study of enterovirus D68 in hospitalised children in Hong Kong in 2014\u20132015 and their complete coding sequences","volume":"6","author":"Wang H","year":"2019","unstructured":"Wang H, Tao K, Leung CY, et\u00a0al. 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