{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:26Z","timestamp":1787018786196,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation of Zhejiang Provincial","award":["LQ18H160015"],"award-info":[{"award-number":["LQ18H160015"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Circular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction\u2013associated steatotic liver disease. This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction\u2013associated steatotic liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Quantitative reverse transcription polymerase chain reaction was performed to determine\n                      <jats:italic>circDock6<\/jats:italic>\n                      expression patterns in liver tissues from high-fat diet- and standard diet-fed mice in vivo. Triglyceride detection, western blot analysis, and oil red O staining were performed to evaluate the regulatory effect of circDock6 on metabolic dysfunction\u2013associated steatotic liver disease in vitro.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>CircDock6<\/jats:italic>\n                      was found to be markedly overexpressed in high-fat diet liver tissues compared with that in standard diet tissues. Moreover, knockdown of\n                      <jats:italic>circDock6<\/jats:italic>\n                      expression lowered triglyceride content and lipid droplet formation. Mechanistically, circDock6 acted as a molecular sponge for mmu-let-7g-5p, which regulated insulin-like growth factor 1 receptor expression and contributed to the progression of metabolic dysfunction\u2013associated steatotic liver disease.\n                      <jats:italic>CircDock6<\/jats:italic>\n                      knockdown suppressed metabolic dysfunction\u2013associated steatotic liver disease progression by modulating insulin-like growth factor 1 receptor via mmu-let-7g-5p targeting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study identified circDock6 as a novel regulator of metabolic dysfunction\u2013associated steatotic liver disease pathogenesis through the mmu-let-7g-5p\/insulin-like growth factor 1 receptor axis, indicating its potential as a therapeutic target for metabolic dysfunction\u2013associated steatotic liver disease intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251362984","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:51:47Z","timestamp":1755013907000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["CircDock6 drives metabolic dysfunction\u2013associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p\/insulin-like growth factor 1 receptor regulation"],"prefix":"10.1177","volume":"53","author":[{"given":"Hongpeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-5711","authenticated-orcid":false,"given":"Peifei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.030"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.09.033"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00586"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332398"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305902"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030277"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00255.2023"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ24-0008"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.11.052"},{"key":"e_1_3_9_13_2","doi-asserted-by":"crossref","unstructured":"Li P Yu S Ding X et\u00a0al. CircDock6 promotes NAFLD by regulating IGF1R through targeting mmu-let-7g-5p. Research Square. Epub ahead of print May 2023. DOI: 10.21203\/rs.3.rs-2857513\/v1.","DOI":"10.21203\/rs.3.rs-2857513\/v1"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155380"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaa270"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15193"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23486"},{"key":"e_1_3_9_18_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals","year":"2011","unstructured":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. 8th ed. 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