{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:42:33Z","timestamp":1778560953594,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Brucellosis is a zoonotic disease with significant global health implications, particularly in endemic regions such as Saudi Arabia. It is characterized by clinical manifestations that mimic both infectious and noninfectious diseases, making diagnosis challenging. Congenital brucellosis, a rare entity, can be transmitted transplacentally from a bacteremic mother or through exposure to maternal secretions during delivery. This report describes the case of a neonate with extremely low birth weight and severe respiratory distress syndrome, who was ultimately diagnosed with congenital brucellosis caused by\n                    <jats:italic toggle=\"yes\">Brucella melitensis<\/jats:italic>\n                    . Despite treatment with trimethoprim\u2013sulfamethoxazole (TMP\/SMX) and rifampin, the infant developed abdominal distension and hypotension, showed a clinical picture consistent with sepsis, and succumbed on day 28 of life. This report underscores the importance of early recognition and management of congenital brucellosis to improve outcomes and highlights gaps in antenatal screening and preventive strategies. Diagnosis was confirmed by isolating\n                    <jats:italic toggle=\"yes\">B. melitensis<\/jats:italic>\n                    from blood culture using standard microbiological methods. The patient was treated with trimethoprim\u2013sulfamethoxazole (8\u2009mg\/kg\/day) and rifampin (10\u2009mg\/kg\/day). Clinical signs such as persistent hypoxemia and abdominal distension developed before death on day 28. Antenatal screening gaps in endemic regions such as Saudi Arabia contributed to delayed diagnosis.\n                  <\/jats:p>","DOI":"10.1177\/03000605251369762","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:34:52Z","timestamp":1763004892000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Congenital brucellosis in a newborn: A rare case report and clinical insights"],"prefix":"10.1177","volume":"53","author":[{"given":"Abdulrahman O","family":"Alghamdi","sequence":"first","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulelah S","family":"Algethami","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Salman Specialized \u2013 National Guard Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejood M","family":"Aljaed","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A","family":"Alharthi","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed S","family":"Aljuaeed","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan A","family":"Jafri","sequence":"additional","affiliation":[{"name":"Pediatric Department, Alhada Armed Forces Hospital, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma AS","family":"Abosabie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A","family":"Abosabie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-3838","authenticated-orcid":false,"given":"Naglaa M","family":"Kamal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520975576"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/523726"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92090-6"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml029"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2018.4.21896"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2018.2280"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.8938"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519838921"},{"key":"e_1_3_7_11_2","first-page":"433","article-title":"Prematurity due to maternal brucella infection and review of the literature","volume":"55","author":"Aydin B","year":"2013","unstructured":"Aydin B, Beken S, Akansel R, et\u00a0al. Prematurity due to maternal brucella infection and review of the literature. Turk J Pediatr 2013; 55: 433\u2013437.","journal-title":"Turk J Pediatr"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2012.1165"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-011-0581-z"},{"key":"e_1_3_7_14_2","first-page":"29\u201331","article-title":"Congenital brucellosis in an infant","volume":"2","author":"Imani R","year":"2007","unstructured":"Imani R, Shamsipoor E, Khadivi R. Congenital brucellosis in an infant. Arch Clin Infect Dis 2007; 2: 29\u201331.","journal-title":"Arch Clin Infect Dis"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984407"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2002.1043"},{"key":"e_1_3_7_17_2","first-page":"1214","article-title":"A rare congenital Brucellosis re-emerging in Kuwait: a case report","volume":"8","author":"Al-Ayyadhi NH","year":"2023","unstructured":"Al-Ayyadhi NH, Al-Awadhi SS, Al-Shammari FJ, et\u00a0al. A rare congenital Brucellosis re-emerging in Kuwait: a case report. Ann Case Report 2023; 8: 1214.","journal-title":"Ann Case Report"},{"key":"e_1_3_7_18_2","first-page":"272","article-title":"Brucella melitensis in blood cultures of two newborns due to exchange transfusion","volume":"47","author":"Ak\u00e7aku\u015f M","year":"2005","unstructured":"Ak\u00e7aku\u015f M, Esel D, Cetin N, et\u00a0al. Brucella melitensis in blood cultures of two newborns due to exchange transfusion. Turk J Pediatr 2005; 47: 272\u2013274.","journal-title":"Turk J Pediatr"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2014.09.004"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jegh.2015.09.001"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/157489113805290719"},{"key":"e_1_3_7_22_2","first-page":"1","volume-title":"Bacterial and Mycotic Infections in Immunocompromised Hosts; Clinical and Microbiological Aspects","author":"Al-Anazi K","year":"2013","unstructured":"Al-Anazi K, A JA. Brucellosis: a global re-emerging zoonosis history, epidemiology, microbiology, immunology and genetics. In: Mascellino MT (ed) Bacterial and Mycotic Infections in Immunocompromised Hosts; Clinical and Microbiological Aspects. 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