{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:41:59Z","timestamp":1782297719807,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The total cholesterol\/high-density lipoprotein cholesterol ratio is a predictor of nonalcoholic fatty liver disease\u2014a hepatic manifestation of metabolic syndrome. This study investigated the association between total cholesterol\/high-density lipoprotein cholesterol ratio and metabolic syndrome among people living with human immunodeficiency virus on dolutegravir-based antiretroviral therapy in southwestern Uganda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of data obtained from a cross-sectional study of 377 adults who had been on dolutegravir-based antiretroviral therapy for at least 1\u2009year at Ruhoko Health Centre IV, southwestern Uganda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median total cholesterol\/high-density lipoprotein cholesterol ratio was significantly higher in individuals with metabolic syndrome (3.92) than in those without (2.96, p\u202f&lt;\u202f0.001). A statistically significant association was observed between high total cholesterol\/high-density lipoprotein cholesterol ratio and metabolic syndrome (adjusted odds ratios: 2.06, 95% confidence interval: 1.08\u20133.91, p\u2009=\u20090.028). The total cholesterol\/high-density lipoprotein cholesterol ratio at an optimal cutoff of 3.30 had a significant ability (area under the curve \u2009=\u20090.696, 95% confidence interval: 0.642\u20130.750) to differentiate participants with metabolic syndrome from those without at a sensitivity of 73% and specificity of 60%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The total cholesterol\/high-density lipoprotein cholesterol ratio is a significant predictor of metabolic syndrome and serves as a potential blood-based biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251370323","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T23:54:03Z","timestamp":1756511643000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Total cholesterol\/high-density lipoprotein cholesterol ratio is a significant predictor of metabolic syndrome among people on dolutegravir-based antiretroviral therapy: A cross-sectional study in southwestern Uganda"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4235-1003","authenticated-orcid":false,"given":"Charles Nkubi","family":"Bagenda","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Medicine, Mbarara University of Science and Technology, Uganda"},{"name":"Department of Medical Laboratory Science, Uganda Institute of Allied Health and Management Sciences, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Nantongo","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Medicine, Mbarara University of Science and Technology, Uganda"},{"name":"Department of Medical Laboratory, Joint Clinical Research Centre, 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