{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:01:25Z","timestamp":1777726885077,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC) in patients with advanced ovarian cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 200 patients with advanced ovarian cancer were enrolled in this retrospective study and randomly allocated to two groups (research registry number: 11353). On the first day after abdominal closure, routine treatment was performed in the non-HIPEC group, whereas HIPEC was performed in the HIPEC group. The surgical outcomes, overall survival, progression-free survival, side effects, and quality of life of patients were compared between the two groups, and the risk factors for overall survival and progression-free survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The basic information of the patients showed no significant difference between the two groups (p\u2009&gt;\u20090.05). There was no significant difference in the time from surgery to first flatus, postoperative hospital stay, abdominal pain, bleeding, leakage, or other blood indices between the two groups (p\n                      <jats:italic>\u2009<\/jats:italic>\n                      &gt;\n                      <jats:italic>\u2009<\/jats:italic>\n                      0.05); however, the symptoms of ileus and pelvic abscess appeared more frequently in the non-HIPEC group (p\n                      <jats:italic>\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u2009<\/jats:italic>\n                      0.05). HIPEC, tumor size, N stage, T stage, and vascular invasion were significant indicators, while HIPEC, tumor size, vascular invasion, N stage, and T stage were independent prognostic factors. The 3-year survival rate of the HIPEC group (42%) was higher than that of the non-HIPEC group (21%) (p\n                      <jats:italic>\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u2009<\/jats:italic>\n                      0.001). The progression-free survival curve of the HIPEC group was superior to that of the non-HIPEC group (p\n                      <jats:italic>\u2009&lt;\u2009<\/jats:italic>\n                      0.001), and the recurrence rate of the HIPEC group (25%) was lower than that of the non-HIPEC group (49%) (p\n                      <jats:italic>\u2009&lt;\u2009<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIPEC can reduce the possibility of perioperative complications such as intestinal obstruction and pelvic abscess, and the overall survival and progression-free survival curves were better in the HIPEC group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251372415","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:12:41Z","timestamp":1757455961000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy plus surgery in advanced ovarian cancer patients"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1629-6546","authenticated-orcid":false,"given":"Chang","family":"Yanan","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, The Fifth Hospital of Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Ting","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Wuhan Yangtze River Shipping General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Department, Hubei Maternal and Child Health Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yaxin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Dongguan People's Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-2575","authenticated-orcid":false,"given":"Chen","family":"Hong","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Wuhan University Zhongnan Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.649958"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-00969-3"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004853"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201620150107"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-09879-y"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.626924"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.08.003"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.05.006"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.0580"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-023-00496-6"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102168"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.715040"},{"key":"e_1_3_7_14_2","doi-asserted-by":"crossref","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell S","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS, et\u00a0al. 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