{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:55:39Z","timestamp":1793642139690,"version":"4.5.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>This case report described a suspected severe coagulopathy attributed to cefoperazone\/sulbactam, and this adverse reaction might be associated with the inhibition of the vitamin K cycle by cefoperazone\/sulbactam, leading to vitamin K deficiency within the body. We reported a patient diagnosed with bacterial pneumonia, who received cefoperazone\/sulbactam during hospitalization. The patient was administered cefoperazone\/sulbactam via intravenous infusion at a dose of 1.5\u2009g every 8\u2009h for a consecutive treatment period of 23 days. On the 26th day, the patient developed a serious adverse reaction characterized by prolonged clotting time. After treatment with vitamin K1, the coagulation parameters significantly improved by the 28th day (prothrombin time decreased by 88.4%, activated partial thromboplastin time decreased by 61.1%, and international normalized ratio decreased by 88.5%). The Naranjo assessment score was 5, suggesting that the patient\u2019s coagulation disorder could be related to the use of cefoperazone\/sulbactam. This report highlights that patients at high risk of bleeding should be vigilant about the coagulopathy caused by cefoperazone\/sulbactam- and extend the duration of coagulopathy monitoring.<\/jats:p>","DOI":"10.1177\/03000605251375259","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T03:52:23Z","timestamp":1759377143000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe delayed coagulopathy caused by cefoperazone\/sulbactam: A case report"],"prefix":"10.1177","volume":"53","author":[{"given":"Siqin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4096-3402","authenticated-orcid":false,"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.11.012"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158407"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.939203"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-223"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-016-0025-9"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1503713"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1713090"},{"key":"e_1_3_7_9_2","first-page":"68","article-title":"Comparison of the pharmacokinetics of enoxaparin (Clexane) and unfractionated heparin","volume":"556","author":"Dawes J.","year":"1990","unstructured":"Dawes J. 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