{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:24:43Z","timestamp":1788017083348,"version":"build-2784847793"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis aimed to evaluate the efficacy of regenerative endodontic procedures compared with conventional root canal treatment procedures in mature permanent teeth with periapical lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomized controlled trials that were included in the study compared regenerative endodontic procedures with traditional root canal treatment procedures in mature permanent teeth with irreversible pulpitis. The Risk of Bias 2 tool was used for quality assessment, and the certainty of the evidence was evaluated using the GRADE approach. Meta-analysis was performed using the RevMan Web software, using odds ratios for dichotomous outcomes and mean differences for continuous outcomes, with a random-effects model applied. Heterogeneity was assessed using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic, and publication bias was evaluated using funnel plots and Egger's test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included five studies encompassing diverse regenerative strategies. Overall, regenerative endodontic procedures demonstrated comparable or superior clinical and radiographic healing outcomes relative to conventional treatments. Notably, certain regenerative approaches showed greater potential for restoring pulp vitality and reducing early postoperative pain. However, the quality of evidence was moderate, constrained by small sample sizes, methodological heterogeneity, and blinding challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that regenerative endodontic procedures are promising alternatives to conventional root canal treatment procedures for mature teeth with periapical lesions. Despite these encouraging findings, further high-quality, multicenter trials with standardized protocols and extended follow-up periods are necessary to confirm the results and establish the long-term benefits and cost-effectiveness of regenerative endodontics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251379243","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:13:56Z","timestamp":1758932036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative outcomes and success rates of regenerative endodontics versus traditional root canal therapy: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"53","author":[{"given":"Asiya","family":"Mujawar","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sinhgad Dental College and Research Centre, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiyya","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, M.A. Rangoonwala College of Dental Sciences and Research Centre, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, M.A. Rangoonwala College of Dental Sciences and Research Centre, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura A.","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, Dental College, King Saud University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdul","family":"Kader","sequence":"additional","affiliation":[{"name":"Department Restorative Dental Science, College of Dentistry, King Khalid University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alqarni","sequence":"additional","affiliation":[{"name":"Department Restorative Dental Science, College of Dentistry, King Khalid University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-9695","authenticated-orcid":false,"given":"Mohmed Isaqali","family":"Karobari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India"},{"name":"Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, University of Puthisastra, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01872.x"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.11.017"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(90)90070-S"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80483-8"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.04.011"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.09.013"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.10.009"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200404000-00003"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.028"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.08.003"},{"key":"e_1_3_7_12_2","first-page":"712","article-title":"Regeneration of the dentin-pulp complex with revitalisation\/revascularisation therapy: challenges and hopes","volume":"50","author":"Lin LM","year":"2017","unstructured":"Lin LM, Ricucci D, Huang GT. 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Regenerative endodontics versus apexification in teeth with necrotic pulps and immature apices: a systematic review and meta-analysis. J Clin Med 2023; 12: 1178.","journal-title":"J Clin Med"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66305-5"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.04.005"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1616"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13886"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520913242"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70569-7"},{"key":"e_1_3_7_26_2","unstructured":"American Association of Endodontists. 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