{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:02:15Z","timestamp":1777726935492,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Bardet\u2013Biedl syndrome is a rare, pleiotropic genetic disorder. Despite advances in genetic testing, the diagnosis of Bardet\u2013Biedl syndrome remains primarily clinical, particularly in low-resource settings. Clinical features are classified as either primary or secondary. The primary features include retinal dystrophy, central obesity, renal abnormalities, male hypogonadism, and learning disabilities. Secondary characteristics include developmental delay, dental defects, diabetes mellitus, speech disorders, brachydactyly\/syndactyly, and ocular abnormalities such as nystagmus, strabismus, and astigmatism. A significant proportion of patients with Bardet\u2013Biedl syndrome present with behavioral and psychiatric symptoms. It is estimated that one-third of patients with Bardet\u2013Biedl syndrome meet the criteria for a major psychiatric disorder during their lifetime. However, there is a paucity of research on neuropsychiatric traits and their management in Bardet\u2013Biedl syndrome. Herein, we report a case of psychosis in a patient with features of Bardet\u2013Biedl syndrome and describe the multidisciplinary management provided in a psychiatric setting.<\/jats:p>","DOI":"10.1177\/03000605251379249","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:17:58Z","timestamp":1758763078000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosis as a rare neuropsychiatric manifestation of Bardet\u2013Biedl syndrome: A case report"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0390-7958","authenticated-orcid":false,"given":"Selebogo","family":"Moremi","sequence":"first","affiliation":[{"name":"University of Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mpho","family":"Hubona","sequence":"additional","affiliation":[{"name":"University of Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taboka","family":"Maphorisa","sequence":"additional","affiliation":[{"name":"University of Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A","family":"Olashore","sequence":"additional","affiliation":[{"name":"University of Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.12.e76"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-024-01634-7"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.115"},{"key":"e_1_3_7_5_2","volume-title":"GeneReviews(\u00ae)","author":"Forsyth R","year":"1993","unstructured":"Forsyth R, Gunay-Aygun M. Bardet-Biedl syndrome overview. In: Adam MP, Feldman J, Mirzaa GM, et\u00a0al. (eds) GeneReviews(\u00ae). Seattle: University of Washington, 1993."},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.11.002"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-024-03400-w"},{"key":"e_1_3_7_8_2","first-page":"e72003","article-title":"Psychosis in Laurence-Moon syndrome: a case report","volume":"16","author":"Al Fareh N","year":"2024","unstructured":"Al Fareh N, Abbas M, Alosaimi FD. Psychosis in Laurence-Moon syndrome: a case report. 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