{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:02:21Z","timestamp":1777726941180,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the expression of the inflammasome-related molecules NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma tissues and to evaluate their potential as diagnostic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational case\u2013control study, tumor tissues and adjacent noncancerous tissue samples from 25 patients with basal cell carcinoma were analyzed. We quantified NOD-like receptor protein 3 and interleukin-18 expression at the mRNA and protein levels using quantitative real-time polymerase chain reaction and western blotting, respectively. The diagnostic performance of these molecules was assessed using receiver operating characteristic curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results revealed that both NOD-like receptor protein 3 and interleukin-18 were significantly upregulated in basal cell carcinoma tissues compared with adjacent noncancerous tissue samples at the mRNA and protein levels (p\u2009&lt;\u20090.05). Receiver operating characteristic curve analysis demonstrated strong diagnostic performance, with an area under the curve of 0.931 for NOD-like receptor protein 3 (95% confidence interval: 0.845\u20131.00) and 0.860 for interleukin-18 (95% confidence interval: 0.739\u20130.980).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The marked upregulation of NOD-like receptor protein 3 and interleukin-18 suggests their involvement in the inflammatory tumor microenvironment and positions them as promising candidate biomarkers for basal cell carcinoma detection. Although these findings may suggest their relevance as future therapeutic targets, this role requires substantial validation through functional assays and in larger, more diverse study populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251379519","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:13:56Z","timestamp":1758932036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression analysis of NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma: A case\u2013control study"],"prefix":"10.1177","volume":"53","author":[{"given":"Zahra","family":"Mehrabi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Iran"},{"name":"Medical Biology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazanin","family":"Jalilian","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Haghnazari","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Salari","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Kermanshah University of Medical Science, Iran"},{"name":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1974-6860","authenticated-orcid":false,"given":"Soheila","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Iran"},{"name":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jmp5020010"},{"key":"e_1_3_9_3_2","first-page":"4068","article-title":"Inflammation: a key process in skin tumorigenesis","volume":"17","author":"Neagu M","year":"2019","unstructured":"Neagu M, Constantin C, Caruntu C, et\u00a0al. Inflammation: a key process in skin tumorigenesis. Oncol Lett 2019; 17: 4068\u20134084.","journal-title":"Oncol Lett"},{"key":"e_1_3_9_4_2","first-page":"326","article-title":"Ultraviolet radiation and chronic inflammation-molecules and mechanisms involved in skin carcinogenesis: a narrative review","volume":"11","author":"Ci\u0105\u017cy\u0144ska M","year":"2021","unstructured":"Ci\u0105\u017cy\u0144ska M, Olejniczak-Staruch I, Sobolewska-Sztychny D, et\u00a0al. Ultraviolet radiation and chronic inflammation-molecules and mechanisms involved in skin carcinogenesis: a narrative review. 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