{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:50:48Z","timestamp":1786614648448,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100019491","name":"National Natural Science Foundation of China - State Grid Corporation Joint Fund for Smart Grid","doi-asserted-by":"publisher","award":["81900639"],"award-info":[{"award-number":["81900639"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A cohort study of podocyte antigen expression and renal function progression in Chinese patients with membranous nephropathy","award":["20213357018"],"award-info":[{"award-number":["20213357018"]}]},{"name":"Basic Research Program of the Shenzhen Science and Technology R&D Fund","award":["JCYJ20190806163801637"],"award-info":[{"award-number":["JCYJ20190806163801637"]}]},{"name":"Research Program of the Shenzhen Science and Technology","award":["JCYJ20190806162807125"],"award-info":[{"award-number":["JCYJ20190806162807125"]}]},{"name":"Shenzhen Second People\u2019s Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project","award":["(Grant No. 20213357012"],"award-info":[{"award-number":["(Grant No. 20213357012"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK009"],"award-info":[{"award-number":["SZXK009"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults. However, the prognosis of neural epidermal growth factor-like 1\u2013associated membranous nephropathy remains limited and requires further exploration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Chinese retrospective cohort of 446 patients diagnosed with membranous nephropathy on renal biopsy was categorized into phospholipase A2 receptor-associated (n\u2009=\u2009358) and phospholipase A2 receptor\u2013negative (n\u2009=\u200988) membranous nephropathy groups. The phospholipase A2 receptor\u2013negative group was subjected to neural epidermal growth factor-like 1 fluorescence staining. Multivariate regression analyses, stratified analyses, and Kaplan\u2013Meier analyses were used to explore the correlation of neural epidermal growth factor-like 1 with the risk of end-stage renal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 11 cases of neural epidermal growth factor-like 1-associated membranous nephropathy, accounting for 12.7% of phospholipase A2 receptor\u2013negative membranous nephropathy cases. These patients were predominantly young women with a history of fairness cream use. In patients with phospholipase A2 receptor\u2013negative membranous nephropathy, multivariable regression analysis showed that the neural epidermal growth factor-like 1-positive group had a higher risk of end-stage renal disease compared with the neural epidermal growth factor-like 1-negative group (hazard ratio\u2009=\u20093.2, p\u2009=\u20090.026). Stratified analysis showed that this association was particularly significant in patients with systemic lupus erythematosus (hazard ratio\u2009=\u20095.1, p\u2009=\u20090.041). Kaplan\u2013Meier analysis also revealed a higher risk in neural epidermal growth factor-like 1\u2013positive patients (p\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neural epidermal growth factor-like 1 expression is an independent risk factor for end-stage renal disease, especially in patients with systemic lupus erythematosus, with an incidence rate of approximately 12.7% in patients with phospholipase A2 receptor\u2013negative membranous nephropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251379806","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:47:56Z","timestamp":1758840476000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor\u2013negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus"],"prefix":"10.1177","volume":"53","author":[{"given":"Qingqing","family":"Rao","sequence":"first","affiliation":[{"name":"Graduate School of Shenzhen University, China"},{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Yue","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostic Laboratory Group Co. Ltd., China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-1333","authenticated-orcid":false,"given":"Qijun","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2014.11.002"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010093"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810457"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810457"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.06.020"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409354"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018080852"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.09.014"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020081165"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020081165"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.09.016"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12461117"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00303-z"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.10.009"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.09.014"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.039"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012410"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adu2384"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012410"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.07.017"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11860720"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.039"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.10.010"},{"key":"e_1_3_9_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab069"},{"key":"e_1_3_9_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae104"},{"key":"e_1_3_9_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13691"},{"key":"e_1_3_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.03.009"},{"key":"e_1_3_9_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2011.626425"},{"key":"e_1_3_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.03.025"},{"key":"e_1_3_9_32_2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/jama.2020.0292","article-title":"Mercury poisoning from skin cream","volume":"323","author":"Kuehn B.","year":"2020","unstructured":"Kuehn B. 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