{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:19:50Z","timestamp":1777727990304,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Yunnan Province College Student Innovation Training Program Project Fund","award":["Grant No. 202510678050X"],"award-info":[{"award-number":["Grant No. 202510678050X"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>The diagnosis of idiopathic multicentric Castleman disease typically requires serum interleukin-6 testing\u2014often inaccessible in resource-limited settings. A female patient in her early 40s presented with 6-month progressive generalized pruritus, low-grade fever, fatigue, and painless multiregional lymphadenopathy. Laboratory studies showed systemic inflammation, computed tomography\/ultrasound-confirmed bilateral axillary lymphadenopathy, splenomegaly, and serositis. Lymph node biopsy revealed hyaline-vascular features: atrophic germinal centers with a \u201clollipop-like\u201d vasculature and \u201conion skin\u2013like\u201d lymphocyte proliferation. Interleukin-6 testing was unavailable. CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy (nine cycles) combined with thalidomide (100\u2009mg\/day, cycles 6\u20139) was administered. Significant lymph node regression normalized the levels of inflammatory markers, and partial remission was observed at the 1-year follow-up. Rigorous histopathology combined with dynamic inflammatory markers enables the diagnosis of idiopathic multicentric Castleman disease without interleukin-6 testing. CHOP\u2013thalidomide is an effective alternative therapy in resource-constrained regions.<\/jats:p>","DOI":"10.1177\/03000605251381574","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T03:56:14Z","timestamp":1761191774000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic and therapeutic challenges in hyaline-vascular idiopathic multicentric Castleman disease: A case report"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9982-5228","authenticated-orcid":false,"given":"Chengbin","family":"Lu","sequence":"first","affiliation":[{"name":"Kunming Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Lincang People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Luo","sequence":"additional","affiliation":[{"name":"Lincang People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qionghua","family":"Luo","sequence":"additional","affiliation":[{"name":"Lincang People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04762-6"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221080083"},{"key":"e_1_3_9_4_2","first-page":"100720","article-title":"A national, multicenter, retrospective study of castleman disease in China implementing CDCN criteria","volume":"34","author":"Zhang L","year":"2023","unstructured":"Zhang L, Dong Y, Peng H; China Castleman Disease Network (CCDN)et\u00a0al. A national, multicenter, retrospective study of castleman disease in China implementing CDCN criteria. 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