{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:27:56Z","timestamp":1792250876343,"version":"4.4.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to compare the expression patterns of hypoxia-inducible factor-1\u03b1 in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational case\u2013control study included 87 women of childbearing age (20\u201345 years) who underwent ovarian cystectomy at Bal\u0131kesir University Hospital between 2015 and 2020. Of these, 40 patients with confirmed endometriosis constituted the study group, while 47 patients with benign ovarian cysts comprised the control group. Immunohistochemical staining was used to assess the expression of hypoxia-inducible factor-1-alpha in ovarian cyst capsules and endometrial tissue samples. The relationship between the expression of hypoxia-inducible factor-1-alpha and clinical parameters, including age, body mass index, and endometriosis stage, was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression of hypoxia-inducible factor-1-alpha was significantly higher in ovarian cyst capsules and endometrial tissues of patients with endometriosis than in those of controls (p\u2009&lt;\u20090.05). No correlation was found between hypoxia-inducible factor-1-alpha expression and age, body mass index, or disease stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, the expression of hypoxia-inducible factor-1-alpha in the ovarian and endometrial tissues was significantly elevated in patients with endometriosis compared with that in controls, independent of clinical parameters. These results support hypoxia-inducible factor-1-alpha as a stable biomarker of hypoxia in endometriosis and provide a basis for future research on hypoxia-targeted therapies for endometriosis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251386208","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:23:23Z","timestamp":1761272603000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case\u2013control study of ovarian cyst capsules and endometrial tissue samples"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-8518","authenticated-orcid":false,"given":"Ezgi","family":"Tolu Cenk","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyda","family":"Sancakli Usta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Usta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulay","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurhan","family":"Guney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Afsar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Islimye Taskin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bal\u0131kesir University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082815"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1697220"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2284026520987915"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035539"},{"key":"e_1_3_9_6_2","first-page":"399","article-title":"Hypoxia responsive miR-210 promotes cell survival and autophagy of endometriotic cells in hypoxia","volume":"20","author":"Xu TX","year":"2016","unstructured":"Xu TX, Zhao SZ, Dong M, et\u00a0al. Hypoxia responsive miR-210 promotes cell survival and autophagy of endometriotic cells in hypoxia. Eur Rev Med Pharmacol Sci 2016; 20: 399\u2013406.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01180-8"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162772"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1153"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-018-1906-1"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13167"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103205"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13900"},{"key":"e_1_3_9_15_2","first-page":"538","article-title":"Expression of hypoxia-inducible factor-1alpha in endometriosis","volume":"27","author":"Ren X","year":"2007","unstructured":"Ren X, He YL, Pan SL, et\u00a0al. Expression of hypoxia-inducible factor-1alpha in endometriosis. Nan Fang Yi Ke Da Xue Xue Bao 2007; 27: 538\u2013540.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.01.025"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000001148"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115607978"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/22840265221092872"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/2284026518810586"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14916"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad710"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.03.008"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251386208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251386208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251386208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:05Z","timestamp":1777459865000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251386208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/03000605251386208"],"URL":"https:\/\/doi.org\/10.1177\/03000605251386208","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"03000605251386208"}}