{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:20:34Z","timestamp":1777728034291,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effect of preoperative glycopyrrolate and penehyclidine hydrochloride on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, randomized, double-blind, controlled trial enrolled 120 patients who underwent laparoscopic cholecystectomy. Patients were randomly assigned to the glycopyrrolate group, penehyclidine hydrochloride group, or normal saline group. Postoperative nausea and vomiting, hemodynamic parameters, anesthetic consumption, duration of postanesthesia care unit stay, and other perioperative adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of postoperative nausea and vomiting within 1\u2009h in the penehyclidine hydrochloride group was significantly lower than that in the normal saline and glycopyrrolate groups. The heart rate at immediately prior to anesthesia induction, 1\u2009min after endotracheal intubation, the start of surgery, 2\u2009min after pneumoperitoneum, and cholecyst dissection and mean arterial pressure at 1\u2009min after endotracheal intubation and the start of surgery in the normal saline group were significantly lower than those in the glycopyrrolate group. The heart rate at immediately prior to anesthesia induction, 1\u2009min after endotracheal intubation, the start of surgery, and 2\u2009min after pneumoperitoneum and mean arterial pressure at 1\u2009min after endotracheal intubation in the penehyclidine hydrochloride group were markedly lower than those in the glycopyrrolate group. The incidence of bradycardia in the normal saline and penehyclidine hydrochloride groups was significantly higher than that in the glycopyrrolate group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Penehyclidine hydrochloride is more effective than glycopyrrolate in preventing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy, particularly in the early postoperative period.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Chinese Clinical Trial Registry number:<\/jats:bold>\n                      ChiCTR2500107519\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251386355","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T22:02:21Z","timestamp":1762034541000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the effect of preoperative glycopyrrolate and penehyclidine hydrochloride on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized controlled trial"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2314-0463","authenticated-orcid":false,"given":"Hui","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of Yangtze University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renrong","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiangling County People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghui","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of Yangtze University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, the First Affiliated Hospital of Yangtze University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"e45704","article-title":"Laparoscopic cholecystectomy versus open cholecystectomy in acute cholecystitis: a literature review","volume":"15","author":"Mannam R","year":"2023","unstructured":"Mannam R, Sankara Narayanan R, Bansal A, et\u00a0al. Laparoscopic cholecystectomy versus open cholecystectomy in acute cholecystitis: a literature review. Cureus 2023; 15: e45704.","journal-title":"Cureus"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15295"},{"key":"e_1_3_7_5_2","first-page":"1290","article-title":"The 2021 edition of expert consensus of Guangdong Province on the use of anticholinergic drugs before anesthesia","volume":"42","author":"Hei ZQ","year":"2021","unstructured":"Hei ZQ, Hung WQ, Liu KX, et\u00a0al. The 2021 edition of expert consensus of Guangdong Province on the use of anticholinergic drugs before anesthesia. Guangdong Medical Journal 2021; 42: 1290\u20131294. Chinese.","journal-title":"Guangdong Medical Journal"},{"key":"e_1_3_7_6_2","doi-asserted-by":"crossref","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell S","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS, et\u00a0al. CONSORT 2025 statement: updated guideline for reporting randomised trials. BMJ 2025; 389: e081123.","journal-title":"BMJ"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.07.002"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-017-5519-8"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2020.06.001"},{"key":"e_1_3_7_10_2","first-page":"85\u2013113","article-title":"Consensus guidelines for the management of postoperative nausea and vomiting","volume":"118","author":"Gan TJ","year":"2015","unstructured":"Gan TJ, Diemunsch P, Habib AS, et\u00a0al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2015; 118: 85\u2013113.","journal-title":"Anesth Analg"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.2.277"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519835700"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-067102"},{"key":"e_1_3_7_14_2","first-page":"1125","article-title":"Guidelines for the perioperative clinical use of glycopyrrolate","volume":"42","author":"Jun L","year":"2021","unstructured":"Jun L, Hao YY, Hong M, et\u00a0al. Guidelines for the perioperative clinical use of glycopyrrolate. International Journal of Anesthesiology and Resuscitation 2021; 42: 1125\u20131132. Chinese.","journal-title":"International Journal of Anesthesiology and Resuscitation"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S177435"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28196"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2024.10.007"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251386355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251386355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251386355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:06Z","timestamp":1777459866000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251386355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/03000605251386355"],"URL":"https:\/\/doi.org\/10.1177\/03000605251386355","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"03000605251386355"}}