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This report presents two cases of angiomyofibroblastoma in the male scrotum to enhance the understanding of this rare condition. In the first case, a man in his early 60s with a recent rectal cancer diagnosis was found to have a palpable right scrotal mass. Imaging suggested metastasis, but radical resection and pathological analysis confirmed angiomyofibroblastoma, with no evidence of testicular malignancy. The patient remained tumor-free for 7 years. In the second case, a man in his early 40s presented with a nontender, slowly enlarging right inguinal mass extending into the scrotum. Surgical resection revealed a 6\u2009\u00d7\u20094-cm angiomyofibroblastoma, with no recurrence for 7 years. These cases underscore the importance of considering angiomyofibroblastoma in the differential diagnosis of scrotal masses in males. Accurate diagnosis relies on understanding the clinical, imaging, and histopathologic features of angiomyofibroblastoma to ensure appropriate management and favorable outcomes.<\/jats:p>","DOI":"10.1177\/03000605251386617","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T02:53:55Z","timestamp":1760756035000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Angiomyofibroblastoma of the scrotum: A report of two cases and literature review"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5898-7255","authenticated-orcid":false,"given":"Qifan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chujin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangqianyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"},{"name":"Department of Urology, School of Medicine, South China University of Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7971"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-106"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_29_20"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199204000-00006"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199801000-00002"},{"key":"e_1_3_6_8_2","first-page":"353","article-title":"Angiomyofibroblastoma of the vulva: a clinicopathological and immunohistochemical analysis of a rare benign mesenchymal tumor","volume":"32","author":"Kairi-Vassilatou E","year":"2011","unstructured":"Kairi-Vassilatou E, Dastamani C, Vouza E, et\u00a0al. 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