{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:01:38Z","timestamp":1789398098113,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"relevant Chinese authorities","award":["No. 2023HL065"],"award-info":[{"award-number":["No. 2023HL065"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hyperuricemia is a common metabolic disorder linked to systemic inflammation; however, its impact on perioperative hematological and inflammatory markers in patients residing in high-altitude regions who have undergone anterior cruciate ligament reconstruction remains unclear. We hypothesized that hyperuricemia is associated with a heightened perioperative inflammatory response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, cross-sectional study included 83 long-term high-altitude (\u22652500\u2009m) residents who underwent anterior cruciate ligament reconstruction between 2019 and 2025. Patients were divided into hyperuricemia (n\u2009=\u200940) and normouricemia (n\u2009=\u200943) groups based on their serum uric acid levels. Inclusion criteria included isolated anterior cruciate ligament injury, complete perioperative laboratory records, and confirmed preoperative hyperuricemia based on serum uric acid levels. Exclusion criteria included systemic inflammatory disease and incomplete data. Perioperative hematological and inflammatory parameters\u2014including platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio\u2014were compared using t-tests and chi-square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperatively, the hyperuricemia group had lower neutrophil-to-lymphocyte ratio (1.17\u2009\u00b1\u20090.92 vs. 1.91\u2009\u00b1\u20090.82,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and platelet-to-lymphocyte ratio (101.6\u2009\u00b1\u200928.4 vs. 116.4\u2009\u00b1\u200931.9,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.028) but higher lymphocyte count (2.21\u2009\u00b1\u20090.56 vs. 1.91\u2009\u00b1\u20090.47,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.009) than the normouricemia group. Postoperatively, compared with the normouricemia group, the hyperuricemia group showed elevated white blood cell count (10.82\u2009\u00b1\u20092.90 vs. 8.23\u2009\u00b1\u20092.55,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), neutrophil count (7.98\u2009\u00b1\u20092.88 vs. 5.55\u2009\u00b1\u20092.23,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lymphocyte count (2.63\u2009\u00b1\u20092.36 vs. 1.75\u2009\u00b1\u20090.52,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.023) but lower platelet-to-lymphocyte ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyperuricemia is associated with altered perioperative hematological profiles and amplified inflammatory responses in patients residing in high-altitude regions who have undergone anterior cruciate ligament reconstruction, underscoring the need for targeted perioperative monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251387874","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:23:23Z","timestamp":1761272603000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperuricemia is associated with altered perioperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and inflammatory responses in patients residing in high-altitude regions who underwent anterior cruciate ligament reconstruction: A cross-sectional study"],"prefix":"10.1177","volume":"53","author":[{"given":"Zheng","family":"Xuemei","sequence":"first","affiliation":[{"name":"North Sichuan Medical College, China"},{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Mengjing","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"},{"name":"Chengdu Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wenling","sequence":"additional","affiliation":[{"name":"North Sichuan Medical College, China"},{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Xiangyue","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"},{"name":"Chengdu Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Dongfa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8664-9068","authenticated-orcid":false,"given":"Cui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing, The General Hospital of the Western Theater Command of the People\u2019s Liberation Army, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2016.08.001"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jeo2.70224"},{"key":"e_1_3_7_4_2","first-page":"495","article-title":"Progress in evaluation of return to sports after anterior cruciate ligament reconstruction","volume":"37","author":"Shi ZL","year":"2023","unstructured":"Shi ZL, Li YL, Yu Y, et\u00a0al. 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