{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:21:20Z","timestamp":1777728080205,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to systematically examine the causal relationships between 19 common dietary factors and the risk of periodontal disease, thereby providing reliable evidence for targeted nutritional interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic instruments for dietary exposures (e.g. alcohol, meats, dairy, fruits, vegetables, and beverages) were derived from the UK Biobank Genome-Wide Association Study database (N\u2009=\u2009421,764\u2013462,630). Outcome data included 97,830 periodontal disease cases and 272,252 controls from FinnGen biobank. Inverse-variance weighted regression served as the primary analysis, supplemented by weighted median and Mendelian randomization\u2013Egger methods for the assessment of pleiotropy and heterogeneity. Sensitivity analyses included Mendelian randomization\u2013Pleiotropy Residual Sum and Outlier for outlier correction and false discovery rate adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After false discovery rate correction and Mendelian randomization\u2013Pleiotropy Residual Sum and Outlier adjustment, inverse-variance weighted analysis identified the following three significant causal associations for periodontal disease risk: higher cheese intake reduced the risk (odds ratio\u2009=\u20090.807, 95% confidence interval: 0.714\u20130.912); higher lamb\/mutton consumption increased the risk (odds ratio\u2009=\u20091.463, 95% confidence interval: 1.138\u20131.880); and habitual added-salt intake elevated the risk (odds ratio\u2009=\u20091.198, 95% confidence interval: 1.081\u20131.327). No significant associations were found for the remaining 16 dietary factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This Mendelian randomization study provides robust evidence showing that cheese consumption may protect against periodontal disease, whereas lamb\/mutton and high added-salt intake elevate the risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251389392","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:39:12Z","timestamp":1762285152000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary intake and periodontal health: Evidence from a Mendelian randomization analysis"],"prefix":"10.1177","volume":"53","author":[{"given":"Fulin","family":"Yan","sequence":"first","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongji","family":"Feng","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Dai","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9778-2456","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Science and Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.09.005"},{"key":"e_1_3_8_3_2","unstructured":"World Health Organization. Oral health https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/oral-health (2025 accessed 5 July 2025)."},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092724"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20065039"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.24-0422"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14405"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07451-2"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_3_8_10_2","unstructured":"UK Biobank. UK Biobank https:\/\/www.ukbiobank.ac.uk (2025 accessed 5 July 2025)."},{"key":"e_1_3_8_11_2","unstructured":"IEU Open GWAS Project. OpenGWAS https:\/\/gwas.mrcieu.ac.uk (2025 accessed 5 July 2025)."},{"key":"e_1_3_8_12_2","unstructured":"Risteys R10. Gingivitis and periodontal diseases https:\/\/r10.risteys.finngen.fi\/endpoints\/K11_GINGIVITIS_PERIODONTAL (2025 accessed 5 July 2025)."},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu4091219"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051035"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070202"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000042417"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2023.06.007"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262861"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.4.989S"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000213888"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24628"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.12.015"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13191"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251389392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251389392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251389392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:13Z","timestamp":1777459873000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251389392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/03000605251389392"],"URL":"https:\/\/doi.org\/10.1177\/03000605251389392","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"03000605251389392"}}