{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:20:59Z","timestamp":1777728059897,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017PH073"],"award-info":[{"award-number":["ZR2017PH073"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the short- and long-term effects of neonatal single exposure to propofol anesthesia on neurocognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Institute of Cancer Research mice were intraperitoneally injected with fat emulsion or propofol at a dose of 50 or 100\u2009mg\/kg once at postnatal day 12. At 1, 4, 12, and 24 weeks following anesthesia, learning and memory abilities were evaluated using the novel object recognition and Morris water maze experiments. Histopathology and synaptic function of the hippocampus were assessed using hematoxylin and eosin and Golgi-Cox staining, and the expression levels of cyclic adenosine monophosphate\u2013response element binding protein (CREB), brain-derived neurotrophic factor (BDNF), and postsynaptic density protein-95 (PSD95) in the hippocampus were detected using western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference in total exploration time, recognition index, and time and crossings in the target quadrant between the control and propofol-exposed groups. No hippocampal pathological change and abnormal dendritic length or spine density were observed. Furthermore, no significant alterations in the expression levels of CREB, BDNF, or PSD95 were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neonatal single exposure to propofol anesthesia does not impair recognition function in either the short- or long-term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251389799","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:14:17Z","timestamp":1761869657000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short- and long-term effects of single neonatal exposure to propofol anesthesia on cognitive function"],"prefix":"10.1177","volume":"53","author":[{"given":"Shilei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Tongliao People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijing","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Tongliao People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinye","family":"Liu","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaye","family":"Hu","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haorui","family":"Bai","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Sun","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Du","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Yantai University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Tongliao People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4967-7639","authenticated-orcid":false,"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Tongliao People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"54","article-title":"General anesthesia in infants: neurobiological and neuropsychological concerns","volume":"77","author":"J\u00e1uregui-Huerta F","year":"2020","unstructured":"J\u00e1uregui-Huerta F, Redolar-Ripoll D, Cupul-Garc\u00eda JC, et\u00a0al. General anesthesia in infants: neurobiological and neuropsychological concerns. 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