{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:15Z","timestamp":1777726455845,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007764","name":"Lanzhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["No. 2023-2-99"],"award-info":[{"award-number":["No. 2023-2-99"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>This article reports the diagnosis and treatment of a 50-year-old female patient with systemic sclerosis complicated by a nonhealing wound on her left hand. Following comprehensive treatments including debridement, vacuum sealing drainage, ozone therapy, skin grafting, and phalangeal fusion, the wound healed successfully. This article highlights the potentially contradictory role of interleukin-6 inhibitors in the treatment of patients with systemic sclerosis and ulcers as well as emphasizes the application value of ozone therapy in improving tissue hypoxia and promoting healing.<\/jats:p>","DOI":"10.1177\/03000605251391945","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T03:34:05Z","timestamp":1762486445000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic sclerosis complicated by skin ulcers: A case report and literature review"],"prefix":"10.1177","volume":"53","author":[{"given":"Ruonan","family":"Lu","sequence":"first","affiliation":[{"name":"Gansu Provincial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Gansu Provincial Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02639-w"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_3_9_4_2","first-page":"673","article-title":"A case report of systemic sclerosis with esophageal ulcer as the main manifestation","volume":"25","author":"Beili X","year":"2018","unstructured":"Beili X, Yu C, Jian W, et\u00a0al. A case report of systemic sclerosis with esophageal ulcer as the main manifestation. Chinese Journal of Clinical Medicine 2018; 25: 673\u2013675.","journal-title":"Chinese Journal of Clinical Medicine"},{"key":"e_1_3_9_5_2","first-page":"1263","article-title":"Coexistence of systemic sclerosis and ankylosing spondylitis: a case report and literature review","volume":"43","author":"Hu S","year":"2018","unstructured":"Hu S, Zuo X, Li Y. Coexistence of systemic sclerosis and ankylosing spondylitis: a case report and literature review. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018; 43: 1263\u20131265.","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_3_9_6_2","first-page":"267","article-title":"Expression of IL-33 in patients with systemic sclerosis and its correlation with TGF-\u03b2","volume":"12","author":"Su B","year":"2018","unstructured":"Su B, Zhao L, Wu X, et\u00a0al. Expression of IL-33 in patients with systemic sclerosis and its correlation with TGF-\u03b2. Chinese Journal of Clinical Laboratory Science 2018; 12: 267\u2013269.","journal-title":"Chinese Journal of Clinical Laboratory Science"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15166"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31139"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90195-4"},{"key":"e_1_3_9_10_2","first-page":"213","article-title":"A preliminary study on the relationship between hypoxia and skin sclerosis in patients with systemic scleroderma. In: Proceedings of the Second National Academic Conference on Integrated Traditional Chinese and Western Medicine for Allergy and the Inaugural Meeting of the Allergy Professional Committee of the China Association of Integrated Traditional Chinese and Western Medicine","author":"Ming L","year":"2004","unstructured":"Ming L, Wenzhen T. A preliminary study on the relationship between hypoxia and skin sclerosis in patients with systemic scleroderma. In: Proceedings of the Second National Academic Conference on Integrated Traditional Chinese and Western Medicine for Allergy and the Inaugural Meeting of the Allergy Professional Committee of the China Association of Integrated Traditional Chinese and Western Medicine. Dermatology Department, Zhongshan Hospital, Fudan University; Scleroderma Specialty, Shanghai Municipal Hospital of Integrated Traditional Chinese and Western Medicine 2004; 213\u2013214.","journal-title":"Dermatology Department, Zhongshan Hospital, Fudan University; Scleroderma Specialty, Shanghai Municipal Hospital of Integrated Traditional Chinese and Western Medicine"},{"key":"e_1_3_9_11_2","first-page":"2534","article-title":"Advances in the treatment of chronic skin ulcers","volume":"30","author":"Xiwen F","year":"2017","unstructured":"Xiwen F, Bangsheng C. Advances in the treatment of chronic skin ulcers. J Med Theory Pract 2017; 30: 2534\u20132536.","journal-title":"J Med Theory Pract"},{"key":"e_1_3_9_12_2","first-page":"35","article-title":"Analysis of clinical characteristics in 124 patients with systemic sclerosis","volume":"7","author":"Jiaqian Z","year":"2018","unstructured":"Jiaqian Z, Wenzhen T. Analysis of clinical characteristics in 124 patients with systemic sclerosis. Rheumatism and Arthritis 2018; 7: 35\u201339.","journal-title":"Rheumatism and Arthritis"},{"key":"e_1_3_9_13_2","first-page":"64","article-title":"A case of disability caused by systemic sclerosis characterized by phalangeal osteolysis","volume":"19","author":"Nana G","year":"2017","unstructured":"Nana G, Xuejun L, Zili F, et\u00a0al. A case of disability caused by systemic sclerosis characterized by phalangeal osteolysis. China Modern Medicine Journal 2017; 19: 64\u201365.","journal-title":"China Modern Medicine Journal"},{"key":"e_1_3_9_14_2","first-page":"368","article-title":"Treatment experience of chronic non-healing wounds in high-altitude areas","volume":"19","author":"Yanan A.","year":"2019","unstructured":"Yanan A. Treatment experience of chronic non-healing wounds in high-altitude areas. World Latest Med Inf (Cont Electron J) 2019; 19: 368.","journal-title":"World Latest Med Inf (Cont Electron J)"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2234081"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.04.005"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/255332a0"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16093"},{"key":"e_1_3_9_19_2","first-page":"133","article-title":"Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes","volume":"7","author":"Bocci V","year":"1993","unstructured":"Bocci V, Luzzi E, Corradeschi F, et\u00a0al. Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes. J Biol Regul Homeost Agents 1993; 7: 133\u2013138.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_9_20_2","first-page":"510","article-title":"Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes","volume":"75","author":"Bocci V","year":"1990","unstructured":"Bocci V, Paulesu L. Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica 1990; 75: 510\u2013515.","journal-title":"Haematologica"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/09629359990360"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.12.393"},{"key":"e_1_3_9_23_2","first-page":"E115","article-title":"Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"Magalhaes FN","year":"2012","unstructured":"Magalhaes FN, Dotta L, Sasse A, et\u00a0al. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Phys 2012; 15: E115\u2013E129.","journal-title":"Pain Phys"},{"key":"e_1_3_9_24_2","first-page":"43","article-title":"[Antimicrobial action of ozone in the treatment of mandibular fracture]","author":"Malanchuk VA","year":"2000","unstructured":"Malanchuk VA, Gorshevikova EV, Kopchak AV. [Antimicrobial action of ozone in the treatment of mandibular fracture]. Klin Khir 2000; 43\u201346.","journal-title":"Klin Khir"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251391945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251391945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251391945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:35Z","timestamp":1777459595000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251391945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/03000605251391945"],"URL":"https:\/\/doi.org\/10.1177\/03000605251391945","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"03000605251391945"}}