{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:32Z","timestamp":1777726472515,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early rhythm control has demonstrated clinical benefits even among patients with persistent atrial fibrillation. However, some patients continue to experience recurrent atrial tachyarrhythmias despite undergoing catheter ablation and treatment with antiarrhythmic drugs. This study aimed to assess the efficacy of digoxin in restoring sinus rhythm among patients with recurrent atrial tachyarrhythmias after catheter ablation and ongoing medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 1 January 2013 and 1 September 2023, a total of 194 patients underwent catheter ablation for persistent atrial fibrillation. Among these, 96 (49.5%) patients experienced recurrence of atrial tachyarrhythmia during follow-up after catheter ablation. Of these, 12 patients with sustained arrhythmias despite at least 1 month of treatment with antiarrhythmic drugs and rate-control medications were treated with digoxin. Patients who achieved sinus rhythm after digoxin administration were categorized as the digoxin-effective group, and those who did not were classified as the non\u2013digoxin-effective group. Clinical characteristics, medications, and echocardiographic parameters were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 12 patients analyzed (mean age: 66\u2009\u00b1\u20097 years; 3 males and 9 females), 7 (58.3%) achieved sinus rhythm after digoxin administration. Patients in the digoxin-effective group exhibited significantly smaller left atrial sizes than those in the non\u2013digoxin-effective group (39.2\u2009\u00b1\u20093.3\u2009mm vs. 46.8\u2009\u00b1\u20092.6\u2009mm, p\u2009=\u20090.017). Most recurrences in the digoxin-effective group were atrial tachycardia episodes (5\/7, 71.4%). The median duration from digoxin initiation to sinus rhythm restoration was 49\u2009days (range: 21\u2013210\u2009days). No serious adverse effects occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Digoxin effectively restored sinus rhythm in selected patients experiencing recurrent atrial tachyarrhythmias after catheter ablation and ongoing medical therapy, particularly among those with smaller left atrial sizes. Further research is warranted to validate these findings and explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251395565","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:53:51Z","timestamp":1763686431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of digoxin on sinus rhythm restoration after catheter ablation of persistent atrial fibrillation and drug-refractory atrial tachyarrhythmia recurrence: A cohort study"],"prefix":"10.1177","volume":"53","author":[{"given":"Yu-Sheng","family":"Lin","sequence":"first","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Hsuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang-Yan","family":"Hou","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital"},{"name":"School of Medicine, College of Medicine, National SunYat-sen University, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-0880","authenticated-orcid":false,"given":"Yung-Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital"},{"name":"School of Medicine, College of Medicine, National SunYat-sen University, Taiwan"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae176"},{"key":"e_1_3_8_3_2","first-page":"3","article-title":"European Society of Cardiology (ESC) guidelines on atrial fibrillation 2024: what is new and what is important?]","volume":"50","author":"H\u00e4ttasch R","year":"2025","unstructured":"H\u00e4ttasch R, Tscholl V, Hindricks G, et\u00a0al. 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