{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:41Z","timestamp":1777726481912,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25H100001"],"award-info":[{"award-number":["LMS25H100001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302020"],"award-info":[{"award-number":["82302020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Cardiac involvement in idiopathic inflammatory myopathies is typically subclinical; however, it is an important predictor of poor prognosis. Although data are limited, including two small cohorts and several case reports, evidence has demonstrated that cardiac involvement in anti-melanoma differentiation\u2013associated gene 5 antibody\u2013positive dermatomyositis is a significant independent predictor of mortality. Here, we summarized the characteristics of two patients with anti-melanoma differentiation\u2013associated gene 5 antibody\u2013positive dermatomyositis who developed fatal cardiac complications, one at early stage and the other during long-term follow-up of the disease. Despite aggressive treatment of the primary condition and intensive life support, both patients ultimately succumbed to their cardiac events. These cases highlight the importance of cardiac evaluation and monitoring in patients with anti-melanoma differentiation\u2013associated gene 5 antibody\u2013positive dermatomyositis.<\/jats:p>","DOI":"10.1177\/03000605251396307","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:53:51Z","timestamp":1763686431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatal cardiac complications in two patients with anti-melanoma differentiation\u2013associated gene 5 antibody\u2013positive dermatomyositis: A dual case report"],"prefix":"10.1177","volume":"53","author":[{"given":"Ning","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-9836","authenticated-orcid":false,"given":"Ci","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-9570","authenticated-orcid":false,"given":"Wenbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-3114","authenticated-orcid":false,"given":"Yongmei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S503928"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06401-x"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.928861"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.765140"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_8_7_2","first-page":"373","article-title":"A systematic review and metaanalysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease","volume":"50","author":"Hannah JR","year":"2023","unstructured":"Hannah JR, Law HE, Gordon T, et\u00a0al. A systematic review and metaanalysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease. J Rheumatol 2023; 50: 373\u2013383.","journal-title":"J Rheumatol"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-005276"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab851"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez076"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101220"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-021-00180-9"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12300"},{"key":"e_1_3_8_14_2","doi-asserted-by":"crossref","unstructured":"Yu C Wu C Jin S et\u00a0al. The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies. J Am Acad Dermatol. 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