{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:47Z","timestamp":1777726487471,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Palmoplantar warts are among the most common types of warts and are often challenging to treat. Currently, only a few effective treatments exist for palmoplantar warts. This study aimed to compare the efficacy and safety of 0.05% topical calcipotriol ointment and liquid nitrogen spray in the treatment of palmoplantar warts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-eight adult patients with palmoplantar warts were randomly assigned to two groups. Thirty patients in Group A were treated with 0.05% topical calcipotriol twice daily, while twenty-eight patients in Group B received liquid nitrogen spray biweekly. Both treatments were administered for 8 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Statistically significant reductions in wart number and size were observed in both groups at weeks 4 and 8; however, the differences between the two groups were not statistically significant. Most adverse events in the calcipotriol group were mild, while those in the liquid nitrogen group included pain (82.14%), vesicular lesions (78.57%), erythema (42.86%), bleeding (3.57%), and edema (3.57%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both treatments demonstrated comparable efficacy; however, topical calcipotriol was safer than liquid nitrogen spray for treating palmoplantar warts. The 0.05% topical calcipotriol ointment may represent a safer alternative to liquid nitrogen spray for the treatment of palmoplantar warts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251396708","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:53:51Z","timestamp":1763686431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical calcipotriol versus liquid nitrogen spray in the treatment of palmoplantar warts: An observational study"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0200-0985","authenticated-orcid":false,"given":"Nguyen Dac Khoi","family":"Nguyen","sequence":"first","affiliation":[{"name":"Pham Ngoc Thach University of Medicine"},{"name":"Anh Tu Clinic, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu Nguyen Anh","family":"Tran","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach University of Medicine"},{"name":"Anh Tu Clinic, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-0497","authenticated-orcid":false,"given":"Hao Trong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach University of Medicine"},{"name":"Anh Tu Clinic, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_128_21"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_39_22"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14122"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1781757"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta10250"},{"key":"e_1_3_7_7_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/ddg.13878","article-title":"Extragenital cutaneous warts\u2013clinical presentation, diagnosis and treatment","volume":"17","author":"Abeck D","year":"2019","unstructured":"Abeck D, Tetsch L, Luftl M, et\u00a0al. Extragenital cutaneous warts\u2013clinical presentation, diagnosis and treatment. J Dtsch Dermatol Ges 2019; 17: 613\u2013634.","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.05.024"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1789540"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13712"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2024.100264"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003846"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3427026"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04190.x"},{"key":"e_1_3_7_15_2","first-page":"184","article-title":"Comparison of efficacy of liquid nitrogen and vitamin D3 in treatment of warts on hands and feet","volume":"31","author":"Amin U","year":"2021","unstructured":"Amin U, Fatima H, Kehkshan K, et\u00a0al. Comparison of efficacy of liquid nitrogen and vitamin D3 in treatment of warts on hands and feet. J Pak Assoc Dermatol 2021; 31: 184\u2013190.","journal-title":"J Pak Assoc Dermatol"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.61919\/jhrr.v4i1.487"},{"key":"e_1_3_7_18_2","first-page":"1304","article-title":"Comparison of intralesional vitamin D3 versus cryotherapy for management of plantar warts","volume":"69","author":"Yousaf F","year":"2019","unstructured":"Yousaf F, Raza N, Ahmed N, et\u00a0al. Comparison of intralesional vitamin D3 versus cryotherapy for management of plantar warts. Pak Armed Forces Med J 2019; 69: 1304\u20131308.","journal-title":"Pak Armed Forces Med J"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5236290"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.10.059"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12816"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251396708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251396708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251396708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:43Z","timestamp":1777459603000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251396708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/03000605251396708"],"URL":"https:\/\/doi.org\/10.1177\/03000605251396708","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"article-number":"03000605251396708"}}