{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:24Z","timestamp":1787018784915,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB25069043"],"award-info":[{"award-number":["AB25069043"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Province Natural Science Foundation","award":["2023GXNSFAA026169"],"award-info":[{"award-number":["2023GXNSFAA026169"]}]},{"name":"Science and Technology Plan of Guilin","award":["20230135-1-1"],"award-info":[{"award-number":["20230135-1-1"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460158"],"award-info":[{"award-number":["82460158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystitis glandularis is a metaplastic lesion of the bladder mucosa. The underlying pathogenesis of cystitis glandularis and the potential association between the therapeutic effects of pachymic acid and ferroptosis remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Human bladder epithelial cells (SV40-immortalized human urothelial cells-1 (SV-HUC-1)) and Sprague\u2013Dawley rat bladders were treated with lipopolysaccharide, with pachymic acid and ferrostatin-1 used as interventions. Cell viability was determined using the Cell Counting Kit-8 (CCK-8) assay. Levels of reactive oxygen species, glutathione, and malondialdehyde were quantified in both cells and tissues. Levels of tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interleukin-6 in rat bladder tissues were quantified using enzyme-linked immunosorbent assay kits. The expression levels of nuclear factor erythroid 2-related factor 2, glutathione peroxidase 4, and solute carrier family 7 member 11 were analyzed, and bladder inflammation was evaluated using hematoxylin and eosin staining. The mitochondrial ultrastructure of bladder tissue was examined using transmission electron microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lipopolysaccharide treatment reduced cell viability, increased malondialdehyde and reactive oxygen species levels, and decreased glutathione levels in both cells and tissues. The levels of nuclear factor erythroid 2 related factor 2, glutathione peroxidase 4, and solute carrier family 7 member 11 were reduced, while those of inflammation markers were elevated. Lipopolysaccharide stimulation induced mitochondrial structural damage in rat bladder tissues. Treatment with pachymic acid and ferrostatin-1 partially reversed these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ferroptosis plays a critical role in lipopolysaccharide-induced cystitis glandularis. Pachymic acid may alleviate cystitis glandularis by inhibiting ferroptosis, offering a novel therapeutic strategy for the clinical management of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251396755","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:15:27Z","timestamp":1764216927000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis"],"prefix":"10.1177","volume":"53","author":[{"given":"Yongbo","family":"Tang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guilin Medical University"},{"name":"Guilin Medical University"},{"name":"Guilin Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Hu","sequence":"additional","affiliation":[{"name":"The Second 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