{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:55:15Z","timestamp":1777726515094,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This case\u2013control study aimed to investigate whether peri-appendiceal inflammation is associated with orifice stenosis and appendiceal body thickening in patients with ulcerative colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from patients with ulcerative colitis\u2014including demographics, symptoms, medications, clinical signs, diagnosis, laboratory tests, colonoscopy findings, and abdominal computed tomography\u2014were recorded and analyzed. Orifice stenosis was defined as apparent narrowing or disappearance of the appendiceal orifice compared with the nearest cecal fold. A thickened appendiceal body was defined as an appendiceal &gt;6\u2009mm with or without surrounding inflammatory changes on computed tomography. The severity of peri-appendiceal inflammation was scored using the Mayo endoscopic score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 169 patients with ulcerative colitis were included, of whom 17.2% (29\/169) had appendiceal orifice stenosis. Appendiceal orifice stenosis was associated with age (odds ratio: 1.042,\n                      <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                      =\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.008) and the peri-appendiceal inflammation score (odds ratio: 3.382,\n                      <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                      &lt;\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.001). Among 42 patients who underwent abdominal computed tomography, 69.0% (29\/42) had appendiceal body thickening. None of these 29 patients had a positive McBurney sign or a flare of acute appendicitis. Appendiceal width was associated with the peri-appendiceal inflammation score (odds ratio: 4.172,\n                      <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                      =\n                      <jats:italic toggle=\"yes\">\u2009<\/jats:italic>\n                      0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Appendiceal orifice stenosis and appendiceal body thickening are prevalent in patients with ulcerative colitis. Peri-appendiceal inflammation is associated with the severity of stenosis and appendiceal width, suggesting it may serve as an indirect indicator of appendiceal inflammation related to ulcerative colitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251403377","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:20:51Z","timestamp":1765844451000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri-appendiceal inflammation is associated with appendiceal orifice stenosis and appendiceal body thickening in ulcerative colitis: A case\u2013control study"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-5285","authenticated-orcid":false,"given":"Ting","family":"Yi","sequence":"first","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zejun","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-8481","authenticated-orcid":false,"given":"Ruifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-5846","authenticated-orcid":false,"given":"Yutang","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Tsinghua Changgung Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.042"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.301"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3129-z"},{"key":"e_1_3_10_5_2","first-page":"109","article-title":"[A case of appendiceal lesion prior to the manifestation of ulcerative colitis: so-called \u201culcerative appendicitis\u201d as an antecedent lesion]","volume":"93","author":"Takizawa H","year":"1996","unstructured":"Takizawa H, Yamaguchi O, Kaizu M, et\u00a0al. 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