{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:02:44Z","timestamp":1777726964821,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Peking University International Hospital Internal Grant","award":["YN2021QN03"],"award-info":[{"award-number":["YN2021QN03"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was conducted to evaluate the predictive value of endoscopic measurements of cardia opening diameter and sliding hernia length for diagnosing gastroesophageal reflux disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 233 patients with typical gastroesophageal reflux disease symptoms who underwent endoscopy and esophageal pH-impedance monitoring between September 2017 and September 2023 were enrolled in this study. Cardia opening diameter and sliding hernia length were measured during endoscopy under adequate gastric insufflation. Using esophageal pH-impedance monitoring as the gold standard (with acid exposure time &gt;4% as the diagnostic criterion for gastroesophageal reflux disease), the correlation between cardia opening diameter\/sliding hernia length and gastroesophageal reflux disease-related parameters was analyzed. A nomogram prediction model was subsequently developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The optimal cutoff values for predicting pathological acid reflux were cardia opening diameter &gt;2\u2009cm and sliding hernia length &gt;1\u2009cm (area under the receiver operating characteristic curve\u2009=\u20090.648 for both). Compared with patients with a cardia opening diameter \u22642\u2009cm, those with a cardia opening diameter &gt;2\u2009cm had significantly higher acid exposure time (6.8% vs. 2.5%), DeMeester score (25.7 vs. 10.9), and number of reflux episodes (108 vs. 59) (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similarly, sliding hernia length &gt;1\u2009cm was associated with more severe reflux parameters (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and was more prevalent in males (72.4% vs. 43.6%). Univariate and multivariate logistic regression analyses demonstrated that a nomogram incorporating age, body mass index, and sliding hernia length exhibited good predictive performance (area under the curve\u2009=\u20090.739).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endoscopically assessed cardia opening diameter and sliding hernia length are useful functional predictors of gastroesophageal reflux disease. The integrated prediction model may serve as a valuable diagnostic aid, especially in primary care or resource-limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251409497","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:05:51Z","timestamp":1767917151000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic assessment of the gastroesophageal junction for predicting gastroesophageal reflux disease"],"prefix":"10.1177","volume":"54","author":[{"given":"Xue","family":"Fan","sequence":"first","affiliation":[{"name":"Peking University International Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiran","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University International Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University International Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-8826","authenticated-orcid":false,"given":"Xiangchun","family":"Lin","sequence":"additional","affiliation":[{"name":"Peking University International Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313589"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.21360"},{"key":"e_1_3_6_4_2","unstructured":"Xuefeng M Jun H Na Li et\u00a0al. Analysis of disease burden and annual change trends of gastroesophageal reflux disease in China from 1990 to 2019. Zhongguo quanke yixue 2024; 27: 2265\u20132271."},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0990-9737"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.13867"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0938-2777"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330616"},{"key":"e_1_3_6_10_2","first-page":"588","article-title":". Chinese guidelines for diagnosis and treatment of gastroesophageal reflux disease","volume":"43","author":"Gastrointestinal Motility Group, Functional Gastrointestinal Disease Group, Esophageal Disease Group, Chinese Society of Gastroenterology. Chinese medical association","year":"2023","unstructured":"Gastrointestinal Motility Group, Functional Gastrointestinal Disease Group, Esophageal Disease Group, Chinese Society of Gastroenterology. Chinese medical association . Chinese guidelines for diagnosis and treatment of gastroesophageal reflux disease. Chinese Journal of Digestion 2023; 43: 588\u2013598.","journal-title":"Chinese Journal of Digestion"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01861-z"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21077"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/26345161241276454"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0413-9"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20279"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10714-0"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2023-001307"},{"key":"e_1_3_6_18_2","first-page":"147","article-title":"Mechanism of obesity in the occurrence and development of gastroesophageal reflux disease","volume":"23","author":"Tusuntuoheti Y","year":"2024","unstructured":"Tusuntuoheti Y, Maimaitiming M, Aili A. Mechanism of obesity in the occurrence and development of gastroesophageal reflux disease. Chinese Journal of Digestive Surgery 2024; 23: 147\u2013152.","journal-title":"Chinese Journal of Digestive Surgery"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-025-00400-2"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i34.3883"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03254-3"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03143-9"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040477"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306223"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_91_24"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6154"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3173-3"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2025.01.003"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/26345161221126961"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251409497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605251409497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605251409497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:15Z","timestamp":1777459695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605251409497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/03000605251409497"],"URL":"https:\/\/doi.org\/10.1177\/03000605251409497","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"03000605251409497"}}