{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:20:25Z","timestamp":1793031625631,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate whether coenzyme Q10 is effective in preventing exercise-induced oxidative stress and muscle damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen randomized controlled studies examining the effects of supplementation with coenzyme Q10 analogs on postexercise oxidative stress and muscle damage were identified through searches in literature databases, including PubMed, the Cochrane Library, Embase, and Web of Science, and then the quality of the included studies was assessed. Quantitative and qualitative analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study screened 14 randomized controlled trials that included a total of 433 subjects. The results demonstrated that oral coenzyme Q10 elevated blood coenzyme Q10 concentration (standardized mean difference: 2.710, 95% confidence interval: 1.57\u20133.85, p\u2009&lt;\u20090.00001) and reduced blood malondialdehyde concentration (standardized mean difference: \u22120.289, 95% confidence interval: \u22120.541 to \u22120.038, p\u2009=\u20090.024). Additionally, oral coenzyme Q10 was found to reduce blood creatine kinase values (standardized mean difference: \u22121.532, 95% confidence interval: \u22122.856 to \u22120.209, p\u2009=\u20090.023), suggesting a potential protective effect on skeletal muscle. The metabolism-related blood lactate and maximal oxygen uptake levels were not affected by coenzyme Q10 (standardized mean difference: \u22120.68, 95% confidence interval: \u22121.89 to 0.53, p\u2009=\u20090.271; standardized mean difference: \u22120.156, 95% confidence interval: \u22120.79 to 0.478, p\u2009=\u20090.630).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coenzyme Q10 may reduce exercise-induced oxidative stress on blood malondialdehyde and exert a protective effect on muscle; however, no effect was observed from the anaerobic and aerobic metabolism of the organism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605251411151","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:27:28Z","timestamp":1770625648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of coenzyme Q10 analogs on oxidative stress, muscle, and metabolism after exercise: A meta-analysis and systematic review"],"prefix":"10.1177","volume":"54","author":[{"given":"Yangqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilang","family":"He","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingling","family":"Ma","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-2054","authenticated-orcid":false,"given":"Zijian","family":"Ma","sequence":"additional","affiliation":[{"name":"Medical School, Nanjing University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002167"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.896503"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091811"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90033-Y"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.09.002"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.929590"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153324"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/465020"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-5-8"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00960K"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000166"},{"key":"e_1_3_7_14_2","first-page":"305","article-title":"Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10","volume":"51","author":"G\u00fcl I","year":"2011","unstructured":"G\u00fcl I, G\u00f6kbel H, Belviranli M, et\u00a0al. 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